Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.40 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.40 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130184 | 0.79 | ALDH1A1 (0.49) | ADORA2AADORA3ADORA2BADORA1TSHR | |
| SCHEMBL3472815 | 0.79 | ADORA2A (0.48) | ADORA2AADORA3ADORA2BADORA1GUCY1B2 | |
| SCHEMBL27256593 | 0.78 | KDM4E (0.43) | TSHRHSD17B10MAPTKDM4EALDH1A1 | |
| SCHEMBL13184352 | 0.77 | KDM4E (0.47) | TSHRHSD17B10MAPTKDM4EALDH1A1 | |
| SCHEMBL3471298 | 0.74 | RXRA (0.63) | RXRANR1H2NR1H3GUCY1B2GUCY1A2 | |
| SCHEMBL23358701 | 0.73 | PTGS1 (0.53) | TSHRHSD17B10MAPTKDM4EALDH1A1 | |
| SCHEMBL3471757 | 0.69 | RXRA (1.00) | RXRANR1H2NR1H3KCNK3 | |
| SCHEMBL6763705 | 0.68 | KDM4E (0.48) | TSHRHSD17B10MAPTKDM4EALDH1A1 | |
| SCHEMBL3436668 | 0.67 | GUCY1B2 (0.56) | ADORA2AADORA3ADORA2BADORA1GUCY1B2 | |
| SCHEMBL3474540 | 0.67 | RXRA (0.69) | RXRANR1H2NR1H3TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | RXRA 18/4885NR1H2 1/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.