Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R38 | P59533 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | CTSV | O60911 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13917978 | 0.81 | GPR84 (0.52) | TAS2R38KDM4EGAAMAPTTDP1 | |
| SCHEMBL10718041 | 0.79 | ERCC1 (0.49) | TAS2R38KDM4EGAAMAPTTDP1 | |
| SCHEMBL1006272 | 0.79 | TAS2R38 (1.00) | TAS2R38KDM4EGAAMAPTTDP1 | |
| SCHEMBL4482962 | 0.79 | MAPT (0.51) | TAS2R38KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL6756097 | 0.78 | TAS2R38 (0.60) | TAS2R38KDM4EGAAMAPTTDP1 | |
| SCHEMBL29948606 | 0.76 | TAS2R38 (0.58) | TAS2R38KDM4EGAAMAPTTDP1 | |
| SCHEMBL5907056 | 0.75 | TAS2R38 (0.56) | TAS2R38KDM4EGAAMAPTTDP1 | |
| SCHEMBL23772153 | 0.75 | GPR84 (0.49) | TAS2R38KDM4EALDH1A1NOTUMLMNA | |
| SCHEMBL25619763 | 0.75 | HDAC6 (0.43) | TAS2R38KDM4EGAAMAPTHPGD | |
| SCHEMBL9371336 | 0.75 | TAS2R38 (0.55) | TAS2R38KDM4EGAAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343050-B1 | 6-PHENYL-3-PIPERAZINYLALKYL 1H,3H-PYRIMIDINEDIONE-2,4 DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPY | SYNTHELABO (FR) | 1992-12-02 | — | — | EP | claimed |
| EP-4182737-B1 | OPTICALLY ACTIVE DEVICES | AMO Ireland (IE) | 2024-07-03 | — | — | EP | disclosed |
| US-20230273456-A1 | OPTICALLY ACTIVE DEVICES | JOHNSON & JOHNSON SURGICAL VISION INC (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230273456-A1 | OPTICALLY ACTIVE DEVICES | JOHNSON & JOHNSON SURGICAL VISION INC (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230273455-A1 | OPTICALLY ACTIVE DEVICES | JOHNSON & JOHNSON SURGICAL VISION INC (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230273455-A1 | OPTICALLY ACTIVE DEVICES | JOHNSON & JOHNSON SURGICAL VISION INC (US) | 2023-08-31 | — | — | US | disclosed |
| US-8334292-B1 | Pyrimidine compounds and methods of making and using same | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2012-12-18 | — | — | US | disclosed |
| US-8334292-B1 | Pyrimidine compounds and methods of making and using same | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2012-12-18 | — | — | US | disclosed |
| US-20100324076-A1 | Novel sEH Inhibitors and their Use | GLAXOSMITHKLINE LLC | 2010-12-23 | — | — | US | disclosed |
| EP-2240021-A1 | NOVEL SEH INHIBITORS AND THEIR USE | GlaxoSmithKline LLC (US) | 2010-10-20 | — | — | EP | disclosed |
| US-4950670-A | Psychological and cardiovascular disorders | SYNTHELABO (FR) | 1990-08-21 | — | — | US | disclosed |
| EP-0172427-B1 | PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER | Shin-Etsu Chemical Co., Ltd. (JP) | 1989-07-05 | — | — | EP | disclosed |
| US-4758639-A | Process for production of vinyl polymer | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1988-07-19 | — | — | US | disclosed |
| US-4757124-A | Suspension or emulsion polymerizing vinyl chloride monomer or mixture of vinyl chloride with vinyl monomer copolymerizable therewith in reactor with walls coated with antiscaling compound containing dye or pigments | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1988-07-12 | — | — | US | disclosed |
| US-4625028-A | 6-aryluracils and selected novel intermediates used in the preparation thereof | THE UPJOHN COMPANY (US) | 1986-11-25 | — | — | US | disclosed |
| US-4593030-A | Use of 6-aryluracils as antiinflammatory and antiarthritic agents | THE UPJOHN COMPANY (US) | 1986-06-03 | — | — | US | disclosed |
| US-4578466-A | Processes for the preparation of 6-aryluracils | THE UPJOHN COMPANY (US) | 1986-03-25 | — | — | US | disclosed |
| EP-0172427-A2 | Process for production of vinyl chloride polymer | Shin-Etsu Chemical Co., Ltd. (JP) | 1986-02-26 | — | — | EP | disclosed |
| US-4521599-A | Process for the preparation of 1,3-oxazine-4-ones | THE UPJOHN COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| US-4495349-A | 6-Aryluracils | THE UPJOHN COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230273456-A1 | OPTICALLY ACTIVE DEVICES | PDE6C, PDE6D, PDE6A | TAS2R38 4055/4885KDM4E 3198/4885GAA 1954/4885 |
| US-20100324076-A1 | Novel sEH Inhibitors and their Use | EPHX1, NCEH1, PCSK9 | TAS2R38 4790/4885KDM4E 886/4885GAA 480/4885 |
| US-20230273455-A1 | OPTICALLY ACTIVE DEVICES | PDE6C, PDE6A, PDE6D | TAS2R38 3988/4885KDM4E 3587/4885GAA 1811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.