Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 5/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20332635 | 0.83 | ALDH1A1 (0.62) | GPR84ALDH1A1MITFTP53KMT2A | |
| SCHEMBL3474886 | 0.75 | TAS2R38 (0.66) | GPR84ALDH1A1TP53NOTUMKDM4E | |
| SCHEMBL13804844 | 0.73 | TP53 (0.50) | ALDH1A1TP53KMT2ANOTUMTNKS2 | |
| SCHEMBL31747883 | 0.72 | ALDH1A1 (0.43) | ALDH1A1MITFTP53KMT2ANOTUM | |
| SCHEMBL6309811 | 0.72 | KMT2A (0.55) | ALDH1A1MITFTP53KMT2ANOTUM | |
| SCHEMBL26846922 | 0.69 | CTSV (0.70) | ALDH1A1TP53KMT2AKDM4ELMNA | |
| SCHEMBL31614575 | 0.69 | CTSV (0.70) | ALDH1A1TP53KMT2AKDM4ELMNA | |
| SCHEMBL186253 | 0.68 | GCGR (0.47) | GPR84ALDH1A1MITFTP53KMT2A | |
| SCHEMBL23758527 | 0.68 | GCGR (0.47) | ALDH1A1MITFTP53KMT2AKDM4E | |
| SCHEMBL16414469 | 0.68 | BRD4 (0.61) | ALDH1A1MITFTP53KMT2ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11679093-B2 | 2-naphthimidamides, analogues thereof, and methods of treatment using same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-06-20 | — | — | US | disclosed |
| US-20210251942-A1 | 2-NAPHTHIMIDAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME | UNIV COLORADO REGENTS (US) | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11679093-B2 | 2-naphthimidamides, analogues thereof, and methods of treatment using same | TMPRSS2, TMPRSS4, TMPRSS15 | GPR84 1913/4885ALDH1A1 2417/4885MITF 3077/4885 |
| US-20210251942-A1 | 2-NAPHTHIMIDAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME | TMPRSS2, TMPRSS4, TMPRSS15 | GPR84 1913/4885ALDH1A1 2417/4885MITF 3077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.