Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475310 | 0.87 | ESR1 (0.48) | THRB | |
| SCHEMBL1919736 | 0.86 | PTGER4 (0.42) | PPARGKMT2A | |
| SCHEMBL3370947 | 0.83 | EPHX1 (0.56) | PPARAPPARG | |
| SCHEMBL6378235 | 0.82 | L3MBTL1 (0.42) | PPARAPPARG | |
| SCHEMBL6382655 | 0.81 | CPN1 (0.48) | — | |
| SCHEMBL9109612 | 0.81 | CTSB (0.42) | PPARAPPARG | |
| Hydrochloric Acid SCHEMBL6378670 | 0.80 | CPN1 (0.47) | — | |
| SCHEMBL8869646 | 0.79 | MEN1 (0.64) | PPARAPPARGKMT2AMEN1ITGB1 | |
| SCHEMBL1919093 | 0.77 | SLC7A5 (0.48) | PPARAPPARGITGB1ITGA4 | |
| SCHEMBL13494459 | 0.77 | SLC7A5 (0.48) | PPARAPPARGITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135975-A1 | Substituted Esters as Cannabinoid-1 Receptor Modulators | MERCK & CO., INC. (US) | 2012-05-31 | — | — | US | disclosed |
| US-7754188-B2 | Radiolabeled cannabinoid-1 receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-07-13 | — | — | US | disclosed |
| EP-2024334-A2 | SUBSTITUTED ESTERS AS CANNABINOID-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007136607-A2 | SUBSTITUTED ESTERS AS CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| EP-1641493-A4 | RADIOLABELED CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| US-20060115425-A1 | Substituted amides | MERCK SHARP & DOHME CORP. | 2006-06-01 | — | — | US | disclosed |
| EP-1641493-A1 | RADIOLABELED CANNABINOID-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005009479-A1 | RADIOLABELED CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060115425-A1 | Substituted amides | CNR1, CNR2, FAAH | PPARA 213/4885PPARG 172/4885KMT2A 2817/4885 |
| US-20120135975-A1 | Substituted Esters as Cannabinoid-1 Receptor Modulators | CNR1, CNR2, FAAH | PPARA 189/4885PPARG 72/4885KMT2A 2455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.