Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811889 | 0.79 | DYRK1A (0.35) | GRM2 | |
| SCHEMBL3475915 | 0.76 | DYRK1A (0.35) | GRM2 | |
| SCHEMBL7819300 | 0.76 | GRM2 (0.39) | GRM2 | |
| SCHEMBL3474766 | 0.75 | GRM2 (0.39) | GRM2 | |
| SCHEMBL3476138 | 0.75 | GRM2 (0.38) | GRM2 | |
| SCHEMBL3476520 | 0.74 | RAB9A (0.41) | — | |
| SCHEMBL3475817 | 0.74 | GRM2 (0.36) | GRM2 | |
| SCHEMBL3476662 | 0.73 | GRM2 (0.35) | GRM2 | |
| SCHEMBL3476991 | 0.73 | GRM2 (0.35) | GRM2 | |
| SCHEMBL3476240 | 0.73 | GRM2 (0.39) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |