Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.36 |
| ▸ | LPL | P06858 | 6/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17439308 | 0.89 | DGAT1 (0.34) | LIPGLPLPDGFRBKDRP4HB | |
| SCHEMBL1554613 | 0.84 | LIPG (0.39) | LIPGLPLPDGFRBKDRP4HB | |
| SCHEMBL1554719 | 0.83 | DGAT1 (0.37) | LIPGLPLPDGFRBKDRP4HB | |
| SCHEMBL25146980 | 0.82 | BACE1 (0.44) | PDGFRBKDRF2F11PRSS1 | |
| SCHEMBL29845293 | 0.82 | BACE1 (0.44) | PDGFRBKDRF2F11PRSS1 | |
| SCHEMBL14804515 | 0.82 | LPL (0.39) | LIPGLPLF11CA1CA2 | |
| Hydrochloric Acid SCHEMBL16109917 | 0.81 | LPL (0.38) | LIPGLPLF11CA1CA2 | |
| SCHEMBL4303492 | 0.81 | LIPG (0.36) | LIPGLPLPDGFRBKDRP4HB | |
| SCHEMBL21610948 | 0.80 | F2 (0.41) | LIPGLPLPDGFRBKDRP4HB | |
| SCHEMBL4553845 | 0.79 | DGAT1 (0.45) | LIPGLPLPDGFRBKDRP4HB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130934-A2 | 2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |