Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ACE | P12821 | 6/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1151 | 0.98 | FOLH1 (0.52) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| SCHEMBL3626589 | 0.98 | FOLH1 (0.52) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| SCHEMBL7274 | 0.98 | FOLH1 (0.52) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| SCHEMBL3626583 | 0.98 | FOLH1 (0.52) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| SCHEMBL19521372 | 0.98 | FOLH1 (0.52) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| SCHEMBL18956324 | 0.97 | FOLH1 (0.51) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| SCHEMBL19615881 | 0.97 | FOLH1 (0.51) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| SCHEMBL5583127 | 0.92 | FOLH1 (0.48) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| SCHEMBL7711554 | 0.92 | FOLH1 (0.48) | FOLH1NAALAD2CA1CA2SLC7A5 | |
| Tyrosine SCHEMBL2432370 | 0.90 | SLC7A5 (0.67) | FOLH1NAALAD2CA1CA2SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7769575-B2 | Three dimensional coordinates of HPTPbeta | Warner Chilcott, LLC (US) | 2010-08-03 | — | — | US | disclosed |
| US-20100030487-A1 | THREE DIMENSIONAL COORDINATES OF HPTPbeta | Aerpio Pharmaceuticals, Inc. | 2010-02-04 | — | — | US | disclosed |
| US-7507568-B2 | Three dimensional coordinates of HPTPbeta | THE PROCTOR & GAMBLE COMPANY (US) | 2009-03-24 | — | — | US | disclosed |
| CN-1812782-A | Pyrazolidinedione derivatives and their use as platelet aggregation inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2006-08-02 | — | — | CN | disclosed |
| US-20060014932-A1 | Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same | VANDERBILT UNIVERSITY | 2006-01-19 | — | — | US | disclosed |
| US-6939952-B2 | Purified and isolated protein zero related (PZR) polypeptide | VANDERBILT UNIVERSITY (US) | 2005-09-06 | — | — | US | disclosed |
| US-20040077065-A1 | Three dimensional coordinates of HPTPbeta | THE PROCTER & GAMBLE COMPANY | 2004-04-22 | — | — | US | disclosed |
| US-20030171565-A1 | Modulating cell signaling, detecting tyrosine kinase or tyrosine phosphatase biological activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-09-11 | — | — | US | disclosed |
| US-6355786-B1 | A NUCLEIC ACID ENCODING A TRANSMEMBRANE PROTEIN THAT BINDS TYROSINE PHOSPHATASE-2; DIAGNOSIS AND THERAPY FOR PROLIFERATIVE AND DIFFERENTIATION DISORDERS; THERAPY FOR TYPE 1B CHARCOT-MARIE TOOTH DISORDER | VANDERBILT UNIVERSITY | 2002-03-12 | — | — | US | disclosed |