Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 1.00 |
| ▸ | METAP2 | P50579 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4950054 | 0.83 | DAO (0.70) | DAOMETAP2KDM4EALOX5LMNA | |
| SCHEMBL3110885 | 0.82 | DAO (0.69) | DAOMETAP2KDM4ELMNAALDH1A1 | |
| SCHEMBL8873789 | 0.77 | KDM4E (0.67) | DAOKDM4ELMNAALDH1A1FEN1 | |
| SCHEMBL3642521 | 0.75 | DAO (0.60) | DAOKDM4ELMNAALDH1A1FEN1 | |
| SCHEMBL15333160 | 0.74 | METAP2 (1.00) | DAOMETAP2ALOX5LMNACHEK1 | |
| SCHEMBL31456431 | 0.74 | METAP2 (1.00) | DAOMETAP2ALOX5LMNACHEK1 | |
| SCHEMBL8649896 | 0.74 | DAO (0.59) | DAOMETAP2KDM4EALOX5ALDH1A1 | |
| SCHEMBL13213412 | 0.74 | DAO (0.59) | DAOMETAP2KDM4EALOX5ALDH1A1 | |
| SCHEMBL612900 | 0.74 | DAO (1.00) | DAOMETAP2ALOX5LMNAALDH1A1 | |
| SCHEMBL3913296 | 0.74 | DAO (0.59) | DAOMETAP2KDM4EALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204278-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204278-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | HCAR1, HCAR2, FFAR1 | DAO 1988/4885METAP2 3574/4885KDM4E 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.