Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.59 |
| ▸ | METAP2 | P50579 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241447 | 0.83 | CHEK1 (0.59) | DAOMETAP2ALOX5CHEK1PIM1 | |
| SCHEMBL2462837 | 0.82 | KDM4E (0.55) | DAOMETAP2CHEK1PIM1RPS6KA3 | |
| SCHEMBL8873683 | 0.77 | KIF11 (0.52) | DAOCAMK2AKIF11DDOPARP1 | |
| SCHEMBL184315 | 0.75 | KDM4E (0.53) | DAOCHEK1CAMK2AKIF11DDO | |
| SCHEMBL30014154 | 0.75 | KDM4E (0.53) | DAOCHEK1CAMK2AKIF11DDO | |
| SCHEMBL612900 | 0.74 | DAO (1.00) | DAOMETAP2ALOX5CHEK1PIM1 | |
| SCHEMBL31456431 | 0.74 | METAP2 (1.00) | DAOMETAP2ALOX5CHEK1PIM1 | |
| SCHEMBL15333160 | 0.74 | METAP2 (1.00) | DAOMETAP2ALOX5CHEK1PIM1 | |
| SCHEMBL8649896 | 0.74 | DAO (0.59) | DAOMETAP2ALOX5CHEK1PIM1 | |
| SCHEMBL3477487 | 0.74 | DAO (1.00) | DAOMETAP2ALOX5CHEK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11839613-B2 | Pyrimidine derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-12-12 | — | — | US | disclosed |
| US-11839613-B2 | Pyrimidine derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-12-12 | — | — | US | disclosed |
| US-11712438-B2 | Phenyl derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-08-01 | — | — | US | disclosed |
| US-11712438-B2 | Phenyl derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-08-01 | — | — | US | disclosed |
| WO-2023133413-A1 | MULTICYCLIC COMPOUNDS | SLAP PHARMACEUTICALS LLC (US) | 2023-07-13 | — | — | WO | disclosed |
| WO-2023096915-A1 | MULTICYCLIC COMPOUNDS | SLAP PHARMACEUTICALS LLC (US) | 2023-06-01 | — | — | WO | disclosed |
| US-20220175775-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-06-09 | — | — | US | disclosed |
| US-11325899-B2 | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-05-10 | — | — | US | disclosed |
| US-11241431-B2 | N-substituted indole derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-02-08 | — | — | US | disclosed |
| EP-3625222-B1 | PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-07-21 | — | — | EP | disclosed |
| EP-2896613-B1 | SULFONAMIDE COMPOUND | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-03-21 | — | — | EP | disclosed |
| US-9487488-B2 | Sulfonamide compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-11-08 | — | — | US | disclosed |
| US-20150307454-A1 | Sulfonamide Compound | KALLYOPE, INC. | 2015-10-29 | — | — | US | disclosed |
| EP-2896613-A1 | SULFONAMIDE COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2015-07-22 | — | — | EP | disclosed |
| US-8859529-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2014042238-A1 | SULFONAMIDE COMPOUND | 田辺三菱製薬株式会社 (JP) | 2014-03-20 | — | — | WO | disclosed |
| US-20120225909-A1 | INDAZOLE ANALOG | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-09-06 | — | — | US | disclosed |
| EP-1610779-B1 | 3-OXO-1,3-DIHYDRO-INDAZOLE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS | LILLY CO ELI (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1610779-B1 | 3-OXO-1,3-DIHYDRO-INDAZOLE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS | LILLY CO ELI (US) | 2009-09-09 | — | — | EP | disclosed |
| US-20060211755-A1 | 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors | ELI LILLY AND COMPANY PATENT DIVISION (US) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11712438-B2 | Phenyl derivatives as PGE2 receptor modulators | PTGER1, PTGER4, PTGER2 | DAO 4464/4885METAP2 4425/4885ALOX5 93/4885 |
| US-20120225909-A1 | INDAZOLE ANALOG | ADRB3, ADRB1, ADRB2 | DAO 800/4885METAP2 2988/4885ALOX5 1266/4885 |
| US-20060211755-A1 | 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors | C5AR2, C3AR1, C5AR1 | DAO 554/4885METAP2 723/4885ALOX5 139/4885 |
| US-20220175775-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | PTGER1, PTGER4, PTGER2 | DAO 3755/4885METAP2 3781/4885ALOX5 167/4885 |
| US-11839613-B2 | Pyrimidine derivatives as PGE2 receptor modulators | PTGER1, PTGER4, PTGER2 | DAO 4096/4885METAP2 4263/4885ALOX5 72/4885 |
| US-20150307454-A1 | Sulfonamide Compound | TRPM8, TRPM5, TRPM7 | DAO 2910/4885METAP2 1069/4885ALOX5 3658/4885 |
| US-11241431-B2 | N-substituted indole derivatives as PGE2 receptor modulators | PTGER1, PTGER4, PTGER2 | DAO 3755/4885METAP2 3781/4885ALOX5 167/4885 |
| US-11325899-B2 | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators | PTGER4, PTGER1, PTGER2 | DAO 4319/4885METAP2 4542/4885ALOX5 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.