Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | TEK | Q02763 | 4/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.40 |
| ▸ | PTPRZ1 | P23471 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28758583 | 0.79 | MEN1 (0.60) | KDRTEKHSP90AA1HSP90AB1MEN1 | |
| SCHEMBL2822823 | 0.77 | NOTUM (0.62) | HSP90AB1NPC1RAB9APTPRZ1PTPN1 | |
| SCHEMBL27850347 | 0.76 | CYP19A1 (0.58) | KDRHSP90AB1NPC1RAB9AMAPT | |
| SCHEMBL10973567 | 0.67 | LMNA (0.59) | NPC1RAB9APTPRZ1PTPN1MAPT | |
| SCHEMBL19813136 | 0.66 | MEN1 (0.58) | KDRTEKHSP90AA1HSP90AB1MEN1 | |
| SCHEMBL13232623 | 0.66 | PTPRZ1 (0.65) | HCRTR1HCRTR2PTPRZ1PTPN1MAPT | |
| SCHEMBL20806026 | 0.65 | — | — | |
| SCHEMBL12219083 | 0.64 | MEN1 (0.64) | HSP90AA1HSP90AB1MEN1NPC1RAB9A | |
| SCHEMBL3977038 | 0.64 | L3MBTL1 (0.44) | HSP90AA1HSP90AB1MEN1NPC1RAB9A | |
| SCHEMBL23431940 | 0.64 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071813-A1 | AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α | ARYX THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | WO | disclosed |