Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.51 |
| ▸ | RXRB | P28702 | 9/20 | 0.51 |
| ▸ | RXRG | P48443 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546134 | 0.85 | RXRA (0.54) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL14119936 | 0.83 | TSHR (0.53) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL2876699 | 0.82 | RXRA (0.54) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL5508804 | 0.82 | RXRA (0.54) | RXRARXRBRXRGKDM4ESSTR4 | |
| SCHEMBL13768229 | 0.81 | RXRA (0.57) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL1852884 | 0.81 | DDB1 (0.47) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL1847055 | 0.81 | TSHR (0.56) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL3479749 | 0.80 | RXRB (0.66) | RXRARXRBRXRGKDM4EHSD17B10 | |
| SCHEMBL14120749 | 0.79 | ACHE (0.45) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL9791358 | 0.79 | RXRA (0.45) | RXRARXRBRXRGALDH1A1SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163781-B2 | Bi-aryl aminotetralines | HOFFMAN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100041714-A1 | BI-ARYL AMINOTETRALINES | BLANC JEAN-BAPTISTE | 2010-02-18 | — | — | US | disclosed |
| US-20100041760-A1 | MONOARYL AMINOTETRALINES | BLANC JEAN-BAPTISTE | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041760-A1 | MONOARYL AMINOTETRALINES | HRH1, HRH4, HRH2 | RXRA 1767/4885RXRB 1535/4885RXRG 1530/4885 |
| US-20100041714-A1 | BI-ARYL AMINOTETRALINES | HRH4, HRH2, HRH1 | RXRA 804/4885RXRB 471/4885RXRG 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.