Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496441 | 0.85 | ALDH1A1 (0.33) | ALDH1A1KDM4EMAPTTDP1MAPK1 | |
| SCHEMBL882975 | 0.85 | ALDH1A1 (0.33) | ALDH1A1KDM4ETDP1APLNRCTSS | |
| SCHEMBL3429563 | 0.84 | KDM4E (0.31) | ALDH1A1KDM4ETDP1APLNRCTSS | |
| SCHEMBL8004421 | 0.84 | ADORA2A (0.39) | ALDH1A1KDM4EMAPTTDP1APLNR | |
| SCHEMBL1496428 | 0.84 | APLNR (0.35) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL15216093 | 0.84 | ALDH1A1 (0.32) | ALDH1A1KDM4ETDP1APLNRCTSS | |
| SCHEMBL3429859 | 0.82 | MAPT (0.35) | ALDH1A1KDM4EMAPTTDP1APLNR | |
| SCHEMBL3478924 | 0.80 | KDM4E (0.39) | ALDH1A1KDM4EMAPTTDP1MAPK1 | |
| SCHEMBL10265556 | 0.79 | CTSS (0.37) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL7944203 | 0.77 | CTSS (0.40) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095211-A1 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095211-A1 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | VIP, EIF2AK2, PREP | ALDH1A1 1706/4885KDM4E 695/4885MAPT 4366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.