Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479997 | 0.85 | SCN9A (0.38) | SCN9AHRH4METAP1MAPK14 | |
| SCHEMBL3233230 | 0.85 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3SCN9ADYRK1A | |
| SCHEMBL3227316 | 0.85 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3SCN9ADYRK1A | |
| SCHEMBL3224719 | 0.84 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3SCN9AHRH4 | |
| SCHEMBL3479740 | 0.83 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3SCN9ADHFR | |
| SCHEMBL3230207 | 0.83 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3SCN9ADYRK1A | |
| SCHEMBL3217462 | 0.82 | SCN9A (0.40) | SLC6A2SLC6A4SLC6A3SCN9AHRH4 | |
| SCHEMBL3234067 | 0.81 | SCN9A (0.46) | SLC6A2SLC6A4SLC6A3SCN9ADYRK1A | |
| SCHEMBL3225679 | 0.81 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3SCN9ADYRK1A | |
| SCHEMBL3226065 | 0.80 | SCN9A (0.45) | SLC6A2SLC6A4SLC6A3SCN9ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096546-B2 | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin | ALBANY MOLECULAR RESEARCH, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20100137287-A1 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137287-A1 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | ADRA1B, ADRB1, ADRA1D | SLC6A2 28/4885SLC6A4 40/4885SLC6A3 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.