Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetaminophen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.95 |
| ▸ | MAPT | P10636 | 3/20 | 0.95 |
| ▸ | MEN1 | O00255 | 3/20 | 0.95 |
| ▸ | CA12 | O43570 | 1/20 | 0.95 |
| ▸ | BRD4 | O60885 | 1/20 | 0.95 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.95 |
| ▸ | CA1 | P00915 | 1/20 | 0.95 |
| ▸ | CA2 | P00918 | 1/20 | 0.95 |
| ▸ | MB | P02144 | 1/20 | 0.95 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.95 |
| ▸ | CA3 | P07451 | 1/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.95 |
| ▸ | RARG | P13631 | 1/20 | 0.95 |
| ▸ | TSHR | P16473 | 1/20 | 0.95 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.95 |
| ▸ | CA4 | P22748 | 1/20 | 0.95 |
| ▸ | CA7 | P43166 | 1/20 | 0.95 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.95 |
| ▸ | CA9 | Q16790 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetaminophen SCHEMBL8204853 | 0.98 | KMT2A (0.91) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8196370 | 0.98 | KMT2A (0.91) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8204785 | 0.98 | KMT2A (0.91) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL252939 | 0.98 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL3480 | 0.98 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8937727 | 0.98 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL5081499 | 0.95 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL20541508 | 0.95 | ALDH1A1 (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL10325382 | 0.95 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8197085 | 0.95 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478297-A | Synthetic preparation method of paracetamol | 山东省科学院菏泽分院 | 2022-05-13 | — | — | CN | claimed |
| CN-103819409-A | Preparation method of 5-difluoromethoxy-2-mercapto-1H-benzimidazole | SHENYANG MANWEI CHEMICAL CO LTD | 2014-05-28 | — | — | CN | claimed |
| CN-103819349-A | Preparation method of 4-(difluoromethoxy)aniline | SHENYANG MANWEI CHEMICAL CO LTD | 2014-05-28 | — | — | CN | claimed |
| CN-101560168-A | Preparation method of benorilate | UNIV NORTHWEST NORMAL (CN) | 2009-10-21 | — | — | CN | claimed |
| US-6160020-A | Alkali metal and alkaline-earth metal salts of acetaminophen | MCNEILL-PPC, INC. (US) | 2000-12-12 | — | — | US | claimed |
| EP-0946163-A2 | SALTS OF ACETAMINOPHEN | McNEIL-PPC, INC. (US) | 1999-10-06 | — | — | EP | claimed |
| WO-1998027931-A2 | SALTS OF ACETAMINOPHEN | MCNEIL-PPC, INC. (US) | 1998-07-02 | — | — | WO | claimed |
| CN-118021783-A | Compound antipyretic analgesic preparation for animals and preparation method thereof | 瑞普（天津）生物药业有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-116973167-A | Sampling device and sampling method for spot check in production process of acetaminophen diclofenac sodium injection | 天津市保灵动物保健品有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-114230496-B | Aromatic sulfinic acid compound and preparation method thereof | 达高工业技术研究院(广州)有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-114478297-A | Synthetic preparation method of paracetamol | 山东省科学院菏泽分院 | 2022-05-13 | — | — | CN | disclosed |
| CN-114478297-A | Synthetic preparation method of paracetamol | 山东省科学院菏泽分院 | 2022-05-13 | — | — | CN | disclosed |
| CN-114230496-A | Aromatic sulfinic acid compound and preparation method thereof | 达高工业技术研究院(广州)有限公司 | 2022-03-25 | — | — | CN | disclosed |
| US-6160020-A | Alkali metal and alkaline-earth metal salts of acetaminophen | MCNEILL-PPC, INC. (US) | 2000-12-12 | — | — | US | disclosed |
| WO-1999066919-A1 | PHARMACEUTICAL COMPOSITION CONTAINING A SALT OF ACETAMINOPHEN AND AT LEAST ONE OTHER ACTIVE INGREDIENT | MCNEIL-PPC, INC. (US) | 1999-12-29 | — | — | WO | disclosed |
| EP-0946163-A2 | SALTS OF ACETAMINOPHEN | McNEIL-PPC, INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| CN-1039535-C | Synthesizing technology of \" Puyantong\ | MEDICINE COLLEGE HUAXI MEDICAL (CN) | 1998-08-19 | — | — | CN | disclosed |
| WO-1998027931-A2 | SALTS OF ACETAMINOPHEN | MCNEIL-PPC, INC. (US) | 1998-07-02 | — | — | WO | disclosed |
| CN-1067881-A | Process for synthesizing paracetamol | MEDICINE COLLEGE HUAXI MEDICAL (CN) | 1993-01-13 | — | — | CN | disclosed |
| US-4279838-A | HYDROLYZING AN N-ACETYLAMINOARYL THIOPHOSPHATE OR PHOSPHATE | MITSUI TOATSU CHEMICALS INC. (JP) | 1981-07-21 | — | — | US | disclosed |