Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694742 | 0.87 | KDM4E (0.73) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL10566656 | 0.87 | KDM4E (0.54) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL10468409 | 0.87 | KDM4E (0.54) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL978291 | 0.86 | KDM4E (0.71) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL1433205 | 0.85 | KDM4E (0.66) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL7172752 | 0.85 | ALDH1A1 (0.67) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL11784892 | 0.85 | KDM4E (0.79) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL1432938 | 0.84 | ALDH1A1 (0.72) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL11786444 | 0.84 | KDM4E (0.69) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10754121 | 0.84 | KDM4E (0.69) | KDM4EALDH1A1CYP1A2CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066413-A1 | FLECAINIDE SYNTHESIS | NARCHEM CORPORATION (US) | 2002-08-29 | — | — | WO | claimed |
| US-4684733-A | Process for the preparation of intermediates of derivatives of pyrrolidine and piperidine | RIKER LABORATORIES, INC. (US) | 1987-08-04 | — | — | US | claimed |
| US-4617396-A | Process for the preparation of derivatives of piperidine | RIKER LABORATORIES, INC. (US) | 1986-10-14 | — | — | US | claimed |
| US-20100056794-A1 | PROCESS FOR THE PREPARATION OF 2,5-BIS-(2,2,2-TRIFLUOROETHOXY)-N-(2-PIPERIDYL-METHYL)-BENZAMIDE AND SALTS THEREOF | GRINDEKS A JOINT STOCK COMPANY (LV) | 2010-03-04 | — | — | US | disclosed |
| EP-1918280-A1 | Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide and salts thereof | "Joint Stock Company Grindeks" (LV) | 2008-05-07 | — | — | EP | disclosed |
| WO-2002066413-A1 | FLECAINIDE SYNTHESIS | NARCHEM CORPORATION (US) | 2002-08-29 | — | — | WO | disclosed |
| US-4824953-A | Multi-step process for producing 5-hydroxy-N-(6-oxo-piperidyl-methyl)-2-(2,2,2-trifluoro-ethoxy)-benzamide and derivatives | RIKER LABORATORIES, INC. (US) | 1989-04-25 | — | — | US | disclosed |
| US-4684733-A | Process for the preparation of intermediates of derivatives of pyrrolidine and piperidine | RIKER LABORATORIES, INC. (US) | 1987-08-04 | — | — | US | disclosed |
| US-4656285-A | Compound 2-acetamidomethyl-6-methoxy-pyridine | RIKER LABORATORIES, INC. (US) | 1987-04-07 | — | — | US | disclosed |
| US-4617396-A | Process for the preparation of derivatives of piperidine | RIKER LABORATORIES, INC. (US) | 1986-10-14 | — | — | US | disclosed |
| US-4555573-A | Certain 6-benzamidomethyl-2(1H)-pyridone derivatives | RIKER LABORATORIES, INC. (US) | 1985-11-26 | — | — | US | disclosed |
| US-4496734-A | Metabolite | RIKER LABORATORIES, INC. (US) | 1985-01-29 | — | — | US | disclosed |
| US-4097481-A | ANTIARRHYTHMIC AGENTS | RIKER LABORATORIES, INC. (US) | 1978-06-27 | — | — | US | disclosed |
| US-4013670-A | ANTIARRHYTHMICS | RIKER LABORATORIES, INC. (US) | 1977-03-22 | — | — | US | disclosed |
| US-4005209-A | Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides | RIKER LABORATORIES, INC. (US) | 1977-01-25 | — | — | US | disclosed |
| US-3996280-A | INTERMEDIATES FOR LOCAL ANESTHETICS AND ARRHYTHMICS | RIKER LABORATORIES, INC. (US) | 1976-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056794-A1 | PROCESS FOR THE PREPARATION OF 2,5-BIS-(2,2,2-TRIFLUOROETHOXY)-N-(2-PIPERIDYL-METHYL)-BENZAMIDE AND SALTS THEREOF | BOLA2; BOLA2B, TET2, CYP1A2 | KDM4E 429/4885ALDH1A1 430/4885CYP1A2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.