SCHEMBL3482377

SCHEMBL3482377

C[Si](C)(C)O[Si](C)(C)CCCOC(=O)/C=C/C(=O)OCCC[Si](C)(C)O[Si](C)(C)C

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.53
HCAR2 Q8TDS4 6/20 0.47
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
TSHR P16473 2/20 0.37
HPGD P15428 1/20 0.37
ALDH1A1 P00352 1/20 0.36
CYP3A4 P08684 1/20 0.36
APP P05067 5/20 0.33
PRKCA P17252 2/20 0.31
LMNA P02545 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8736054 1.00 ATM (0.53) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL9239080 0.93 ATM (0.47) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL3482387 0.93 HCAR2 (0.59) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL3482379 0.93 HCAR2 (0.59) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL9243505 0.93 ATM (0.52) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL8640131 0.91 ATM (0.44) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL1632990 0.91 ATM (0.44) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL8735245 0.91 ATM (0.48) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL9241065 0.90 HCAR2 (0.61) ATMHCAR2MAPTRAB9ANPSR1
SCHEMBL9240955 0.90 ATM (0.43) ATMHCAR2MAPTRAB9ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12428390-B2 Chromene compound and photochromic optical article TOKUYAMA CORPORATION (JP) 2025-09-30 US disclosed
EP-3822296-B1 POLYMER MATERIAL MENICON CO LTD (JP) 2025-09-10 EP disclosed
US-20250115701-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2025-04-10 US disclosed
US-12209154-B2 Polymer material MENICON CO., LTD. (JP) 2025-01-28 US disclosed
EP-3995493-B1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORP (JP) 2024-07-03 EP disclosed
US-20240026145-A1 OPHTHALMIC LENS MENICON CO., LTD. (JP) 2024-01-25 US disclosed
EP-3936091-B1 METHOD FOR ABSORBING OR DISCHARGING WATER IN OPHTHALMIC MEDICAL DEVICE AND OPHTHALMIC MEDICAL DEVICE UNIV TOHOKU (JP) 2023-07-19 EP disclosed
EP-4206797-A1 OPHTHALMIC LENS Menicon Co., Ltd. (JP) 2023-07-05 EP disclosed
US-20220244428-A1 OPHTHALMIC MEDICAL INSTRUMENT INCLUDING PHOTOCHROMIC POLYMER AND PRODUCTION METHOD FOR OPHTHALMIC MEDICAL INSTRUMENT MENICON CO., LTD. (JP) 2022-08-04 US disclosed
US-20220213050-A1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORPORATION (JP) 2022-07-07 US disclosed
US-20070190344-A1 Verification of translation JNC CORPORATION (JP) 2007-08-16 US disclosed
US-20050009982-A1 Compound having silsesquioxane skeleton and its polymer CHISSO CORPORATION (JP) 2005-01-13 US disclosed
US-5786434-A A CURABLE COPOLYMER COMPRISING A DIALKYLACRYLAMIDE OR METHACRYLAMIDE, A VINYLLACTAM, A BIS(SILICON-CONTAINING ALKYL)FUMARATE MONOMERS; RADIATION TRANSPARENT, HIGH OXYGEN PERMEABILITY MENICON CO., LTD. (JP) 1998-07-28 US disclosed
EP-0524557-B1 Ocular lens material MENICON CO LTD (JP) 1996-01-17 EP disclosed
US-5391591-A A curable additional copolymer molding materials having a styrenic monomer, a hydrophilic acrylamide monomer and a crosslinkable vinylbenzyl acrylate monomer; permselectivity, tensile strength, low water absorption MENICON CO., LTD. (JP) 1995-02-21 US disclosed
US-5250583-A Polymer of fluoroalkyl silicon-containing alkyl fumarate, N-vinyllactam, acrylic or methacrylic acid, crosslinkable monomer MENICON CO., LTD. (JP) 1993-10-05 US disclosed
EP-0219884-B1 HARD CONTACT LENS MATERIAL Tomei Sangyo Kabushiki Kaisha (JP) 1993-09-29 EP disclosed
EP-0524557-A2 Ocular lens material Menicon Co., Ltd. (JP) 1993-01-27 EP disclosed
US-5142009-A Crosslinked blend of fumaric acid diesters TOMEI SANGYO KABUSHIKI KAISHA (JP) 1992-08-25 US disclosed
US-4868260-A OXYGEN PERMEABILITY TOMEI SANGYO KABUSHIKI KAISHA (JP) 1989-09-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220213050-A1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE CRY1, CRY2, TRIP13 ATM 929/4885HCAR2 3461/4885MAPT 3612/4885
US-12428390-B2 Chromene compound and photochromic optical article CRY1, CRY2, RAD51 ATM 908/4885HCAR2 3379/4885MAPT 3558/4885
US-20050009982-A1 Compound having silsesquioxane skeleton and its polymer C1S, H1-4, H1-0 ATM 2376/4885HCAR2 2928/4885MAPT 3028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.