Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20801621 | 0.86 | STAT3 (0.44) | STAT3PPARGKEAP1NFE2L2CTDSP1 | |
| SCHEMBL6323071 | 0.81 | CA9 (0.43) | STAT3ALDH1A1NPC1RAB9AMDM2 | |
| SCHEMBL1660141 | 0.79 | STAT3 (0.43) | STAT3CTDSP1SIRT5ALDH1A1NPC1 | |
| SCHEMBL1120039 | 0.79 | STAT3 (0.43) | STAT3CTDSP1SIRT5ALDH1A1NPC1 | |
| SCHEMBL3979818 | 0.79 | STAT3 (0.43) | STAT3CTDSP1SIRT5ALDH1A1NPC1 | |
| SCHEMBL3482999 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2A | |
| SCHEMBL17233364 | 0.78 | CA9 (0.43) | STAT3KEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL5569851 | 0.76 | STAT3 (0.43) | STAT3CTDSP1SIRT5ALDH1A1MEN1 | |
| SCHEMBL29223431 | 0.76 | STAT3 (0.45) | STAT3PPARGKEAP1NFE2L2CTDSP1 | |
| SCHEMBL5665599 | 0.76 | STAT3 (0.45) | STAT3CTDSP1SIRT5ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683092-B2 | Crystalline forms of antidiabetic compounds | MERCK SHARP & DOHME CORP. (US) | 2010-03-23 | — | — | US | disclosed |
| EP-1858844-A4 | NOVEL CRYSTALLINE FORMS OF ANTIDIABETIC COMPOUNDS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | disclosed |
| US-20080221198-A1 | Novel Crystalline Forms of Antidiabetic Compounds | MERCK SHARP & DOHME CORP. | 2008-09-11 | — | — | US | disclosed |
| EP-1858844-A1 | NOVEL CRYSTALLINE FORMS OF ANTIDIABETIC COMPOUNDS | Merck & Co., Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006099077-A1 | NOVEL CRYSTALLINE FORMS OF ANTIDIABETIC COMPOUNDS | MERCK & CO., INC. (US) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221198-A1 | Novel Crystalline Forms of Antidiabetic Compounds | FFAR2, PPARG, PPARA | STAT3 412/4885PPARG 2/4885KEAP1 4218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.