Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3483299 | 0.79 | STAT3 (0.42) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL6825821 | 0.79 | ALDH1A1 (0.64) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL8474920 | 0.76 | ALDH1A1 (0.60) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL6378071 | 0.76 | ALDH1A1 (0.53) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL6048601 | 0.75 | CA12 (0.52) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL7068022 | 0.75 | CYP2D6 (0.43) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL5412108 | 0.74 | HSD11B1 (0.53) | ALDH1A1KMT2AMAPTTP53 | |
| SCHEMBL7584620 | 0.74 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL5685808 | 0.73 | ALDH1A1 (0.51) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL7973971 | 0.73 | MMP2 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683092-B2 | Crystalline forms of antidiabetic compounds | MERCK SHARP & DOHME CORP. (US) | 2010-03-23 | — | — | US | disclosed |
| EP-1858844-A4 | NOVEL CRYSTALLINE FORMS OF ANTIDIABETIC COMPOUNDS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | disclosed |
| US-20080221198-A1 | Novel Crystalline Forms of Antidiabetic Compounds | MERCK SHARP & DOHME CORP. | 2008-09-11 | — | — | US | disclosed |
| EP-1858844-A1 | NOVEL CRYSTALLINE FORMS OF ANTIDIABETIC COMPOUNDS | Merck & Co., Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006099077-A1 | NOVEL CRYSTALLINE FORMS OF ANTIDIABETIC COMPOUNDS | MERCK & CO., INC. (US) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221198-A1 | Novel Crystalline Forms of Antidiabetic Compounds | FFAR2, PPARG, PPARA | ALDH1A1 3241/4885CYP3A4 1124/4885CYP2C9 777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.