Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 14/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3484100 | 0.93 | S1PR3 (0.34) | TRPV4S1PR1S1PR3 | |
| SCHEMBL3483595 | 0.87 | PDPK1 (0.31) | PDPK1 | |
| SCHEMBL3484069 | 0.85 | PDPK1 (0.30) | PDPK1 | |
| SCHEMBL3483637 | 0.85 | TRPV4 (0.32) | TRPV4S1PR1S1PR3PDPK1 | |
| SCHEMBL3483461 | 0.85 | AR (0.33) | TRPV4 | |
| SCHEMBL3483962 | 0.84 | TRPV4 (0.33) | TRPV4S1PR1S1PR3PDPK1 | |
| SCHEMBL14943086 | 0.83 | TRPV4 (0.37) | TRPV4 | |
| SCHEMBL3483565 | 0.81 | TRPV4 (0.32) | TRPV4S1PR1S1PR3PDPK1 | |
| Trifluoroacetic Acid SCHEMBL3480462 | 0.81 | PFKFB4 (0.31) | PDPK1 | |
| Hydrochloric Acid SCHEMBL3483594 | 0.81 | TRPV4 (0.31) | TRPV4S1PR1S1PR3PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440643-B2 | Inhibitors of beta-lactamase | METHYLGENE INC. (CA) | 2013-05-14 | — | — | US | claimed |
| US-20100279983-A1 | NOVEL INHIBITORS OF BETA-LACTAMASE | METHYLGENE INC. | 2010-11-04 | — | — | US | claimed |
| EP-2049200-B1 | NOVEL INHIBITORS OF BETA-LACTAMASE | METHYLGENE INC (CA) | 2015-04-29 | — | — | EP | disclosed |
| US-8440643-B2 | Inhibitors of beta-lactamase | METHYLGENE INC. (CA) | 2013-05-14 | — | — | US | disclosed |
| US-20100279983-A1 | NOVEL INHIBITORS OF BETA-LACTAMASE | METHYLGENE INC. | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279983-A1 | NOVEL INHIBITORS OF BETA-LACTAMASE | MGAM, MGAM2, PGLS | TRPV4 4788/4885S1PR1 4547/4885S1PR3 4709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.