Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.51 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.51 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.51 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.51 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL5326616 | 0.97 | PLA2G2A (0.53) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| Adenosine SCHEMBL844425 | 0.92 | ADORA1 (0.55) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| Adenosine SCHEMBL27722357 | 0.92 | ADORA1 (0.55) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| SCHEMBL19873986 | 0.86 | PLA2G2A (0.62) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| Adenosine SCHEMBL5326610 | 0.84 | ADORA3 (0.53) | SMN1; SMN2ADORA1PLA2G2AAHCY | |
| Adenosine Phosphate SCHEMBL2063219 | 0.83 | P2RY1 (0.75) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| Adenosine SCHEMBL3485281 | 0.82 | ADORA1 (0.48) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| Adenosine Phosphate SCHEMBL5988433 | 0.81 | P2RY1 (0.76) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| Adenosine Phosphate SCHEMBL28225967 | 0.81 | P2RY1 (0.76) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| Adenosine SCHEMBL28057366 | 0.81 | ADORA1 (0.67) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8771714-B2 | Systems and methods for in vivo measurement of interstitial biological activity, processes and/or compositions | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2014-07-08 | — | — | US | disclosed |
| US-20100016697-A1 | SYSTEMS AND METHODS FOR IN VIVO MEASUREMENT OF INTERSTITIAL BIOLOGICAL ACTIVITY, PROCESSES AND/OR COMPOSITIONS | MUSC Foundation for Research Developement (US) | 2010-01-21 | — | — | US | disclosed |
| EP-2097536-A2 | SYSTEMS AND METHODS FOR IN VIVO MEASUREMENT OF INTERSTITIAL BIOLOGICAL ACTIVITY, PROCESSES AND/OR COMPOSITIONS | MUSC Foundation For Research Development (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008055225-A2 | SYSTEMS AND METHODS FOR IN VIVO MEASUREMENT OF INTERSTITIAL BIOLOGICAL ACTIVITY, PROCESSES AND/OR COMPOSITIONS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2008-05-08 | — | — | WO | disclosed |
| US-20050215937-A1 | System and method for filtering leukocytes in cardiac surgery | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-09-29 | — | — | US | disclosed |