Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.32 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485384 | 0.77 | SLC6A4 (0.44) | SLC6A4EPAS1HTR2AKCNH2RAB9A | |
| SCHEMBL29029436 | 0.73 | PTGDR2 (0.61) | SLC6A4PTGDR2SLC6A2SLC6A3HTR2A | |
| SCHEMBL3484951 | 0.73 | PTGDR2 (0.44) | SLC6A4PTGDR2SLC6A2SLC6A3HTR2A | |
| SCHEMBL3485421 | 0.72 | PTGDR2 (0.43) | SLC6A4PTGDR2SLC6A2SLC6A3EPAS1 | |
| SCHEMBL25370095 | 0.70 | PTGDR2 (0.58) | SLC6A4PTGDR2MAPK1HSD17B10NPC1 | |
| SCHEMBL3372357 | 0.70 | PTGDR2 (0.53) | SLC6A4PTGDR2SLC6A2MAPK1HSD17B10 | |
| SCHEMBL14097989 | 0.69 | PTGDR2 (0.49) | SLC6A4PTGDR2SLC6A2SLC6A3HTR2A | |
| SCHEMBL1645241 | 0.67 | SLC6A4 (0.42) | SLC6A4PTGDR2SLC6A2SLC6A3HTR2A | |
| SCHEMBL972400 | 0.66 | CYP2A6 (0.32) | — | |
| SCHEMBL5903450 | 0.65 | LTA4H (0.44) | RAB9AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |