Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.33 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2753212 | 0.80 | MAPK1 (0.55) | SLC6A4HTR2AKCNH2HRH3MEN1 | |
| SCHEMBL3249593 | 0.79 | SLC6A4 (0.40) | SLC6A4HTR2AKCNH2HRH3MEN1 | |
| SCHEMBL3485421 | 0.79 | PTGDR2 (0.43) | PTGDR2NPC1SLC6A4HTR2AKCNH2 | |
| SCHEMBL29029436 | 0.78 | PTGDR2 (0.61) | PTGDR2NPC1SLC6A4HTR2AKCNH2 | |
| SCHEMBL3266556 | 0.77 | KMT2A (0.35) | NPC1SLC6A4HTR2AKCNH2HRH3 | |
| SCHEMBL2753829 | 0.77 | MAPK1 (0.37) | SLC6A4HTR2AKCNH2MEN1KMT2A | |
| SCHEMBL3485703 | 0.74 | PTGDR2 (0.43) | PTGDR2SLC6A4KMT2AALDH1A1MAPK1 | |
| SCHEMBL3485503 | 0.73 | SLC6A4 (0.47) | PTGDR2NPC1SLC6A4HTR2AKCNH2 | |
| SCHEMBL14097989 | 0.73 | PTGDR2 (0.49) | PTGDR2NPC1SLC6A4HTR2AKCNH2 | |
| SCHEMBL5214192 | 0.72 | MAOB (0.41) | SLC6A4MEN1KMT2ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |