⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3486073 | 0.93 | — | — | |
| SCHEMBL8023826 | 0.76 | — | — | |
| SCHEMBL3317288 | 0.76 | — | — | |
| SCHEMBL607241 | 0.76 | — | — | |
| SCHEMBL2099498 | 0.73 | CYP1A2 (0.34) | — | |
| SCHEMBL2100033 | 0.71 | GRM2 (0.31) | — | |
| SCHEMBL1168662 | 0.71 | LTA4H (0.35) | — | |
| SCHEMBL6506199 | 0.71 | L3MBTL1 (0.33) | — | |
| SCHEMBL2226233 | 0.71 | ALDH1A1 (0.34) | — | |
| SCHEMBL249604 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190071399-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SYGNATURE DISCOVERY LTD (GB) | 2019-03-07 | — | — | US | claimed |
| EP-3426649-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Respivert Limited (GB) | 2019-01-16 | — | — | EP | claimed |
| WO-2017153748-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2017-09-14 | — | — | WO | claimed |
| US-11208381-B2 | Indole derivatives and their use as protein kinase inhibitors | RESPIVERT LIMITED (GB) | 2021-12-28 | — | — | US | disclosed |
| US-20210114982-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2021-04-22 | — | — | US | disclosed |
| US-10669235-B2 | Indole derivatives and their use as protein kinase inhibitors | RESPIVERT LIMITED (GB) | 2020-06-02 | — | — | US | disclosed |
| US-20190071399-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SYGNATURE DISCOVERY LTD (GB) | 2019-03-07 | — | — | US | disclosed |
| EP-3426649-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Respivert Limited (GB) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017153748-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2017-09-14 | — | — | WO | disclosed |
| US-8791264-B2 | Benzenesulfonamide compounds and their use as blockers of calcium channels | PURDUE PHARMA L.P. (US) | 2014-07-29 | — | — | US | disclosed |
| US-8247442-B2 | Benzenesulfonamide compounds and their use | PURDUE PHARMA L.P. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20100022595-A1 | Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels | PURDUE PHARMA L.P. (CT) | 2010-01-28 | — | — | US | disclosed |
| US-20090239910-A1 | Benzenesulfonamide Compounds and Their Use | EURO-CELTIQUE S.A. (LU) | 2009-09-24 | — | — | US | disclosed |
| WO-2007118853-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS | EURO-CELTIQUE S.A. (LU) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007110449-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE | EURO-CELTIQUE S.A. (LU) | 2007-10-04 | — | — | WO | disclosed |