Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pirenzepine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.98 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.98 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.98 |
| ▸ | GMNN | O75496 | 1/20 | 0.96 |
| ▸ | APEX1 | P27695 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirenzepine SCHEMBL2732205 | 1.00 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL41705 | 0.99 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL29793172 | 0.99 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL30553045 | 0.99 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL9254860 | 0.99 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL30548470 | 0.98 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL15300969 | 0.98 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL1462692 | 0.98 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL41704 | 0.98 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL5987941 | 0.97 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 781 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240165035-A1 | COATED SOLID PHARMACEUTICAL PREPARATION | SSP CO., LTD. (JP) | 2024-05-23 | — | — | US | claimed |
| CN-117597115-A | Coated solid pharmaceutical preparation | SS制药株式会社 | 2024-02-23 | — | — | CN | claimed |
| EP-4308094-A1 | COATED SOLID PHARMACEUTICAL PREPARATION | SSP Co., Ltd. (JP) | 2024-01-24 | — | — | EP | claimed |
| CN-115252814-A | Cyclodextrin-metal organic framework composition and preparation method thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | claimed |
| WO-2022196818-A1 | COATED SOLID PHARMACEUTICAL PREPARATION | SSP CO., LTD. (JP) | 2022-09-22 | — | — | WO | claimed |
| WO-2021216754-A1 | USE OF P38 MAPK INHIBITORS FOR PREVENTION AND TREATMENT OF AGING AND AGING-RELATED DISORDERS AND FOR BOOSTING AN IMMUNE SYSTEM | Spring Discovery, Inc. (US) | 2021-10-28 | — | — | WO | claimed |
| CN-109627241-A | A kind of easy synthesis technology of medicine for enterogastritis pirenzepine hydrochloride important intermediate | 南京诺希生物科技有限公司 | 2019-04-16 | — | — | CN | claimed |
| CN-106432227-B | A kind of method for preparing pirenzepine hydrochloride key intermediate | 常州大学 | 2017-12-05 | — | — | CN | claimed |
| CN-106220625-B | A kind of synthetic method of pirenzepine hydrochloride key intermediate | 常州大学 | 2017-10-20 | — | — | CN | claimed |
| CN-106432227-A | Pirenzepine hydrochloride key intermediate preparation method | 常州大学 | 2017-02-22 | — | — | CN | claimed |
| EP-1273301-B1 | Pharmaceutical preparations based on active ingredients susceptible to illicit administration | ALTERGON SA (CH) | 2006-09-06 | — | — | EP | claimed |
| US-20060024365-A1 | Novel dosage form | VAYA NAVIN | 2006-02-02 | — | — | US | claimed |
| US-20060018933-A1 | Novel drug delivery system | TORRENT PHARMACEUTICALS LIMITED (IN) | 2006-01-26 | — | — | US | claimed |
| US-20060018934-A1 | Novel drug delivery system | TORRENT PHARMACEUTICALS LIMITED (IN) | 2006-01-26 | — | — | US | claimed |
| CN-1583744-A | Pirenzepine organic acid salt and eye drops for treating myopia | WU JIANMEI (CN) | 2005-02-23 | — | — | CN | claimed |
| CN-1486696-A | Freeze dried pirenzepine powder for injection | 晏四平 | 2004-04-07 | — | — | CN | claimed |
| EP-1273301-A2 | Pharmaceutical preparations based on active ingredients susceptible to illicit administration | ALTERGON S.A. (CH) | 2003-01-08 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5288503-A | WATER-PERMEABLE DIFFUSION BARRIER OF POLYVINYL ALCOHOL | SRCHEM INCORPORATED (US) | 1994-02-22 | — | — | US | claimed |
| US-5260066-A | Cryogel bandage containing therapeutic agent | SRCHEM INCORPORATED (US) | 1993-11-09 | — | — | US | claimed |