Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pirenzepine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 0.98 |
| ▸ | APEX1 | P27695 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirenzepine SCHEMBL29793172 | 1.00 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL9254860 | 1.00 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL30553045 | 1.00 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL30548470 | 0.99 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL348603 | 0.99 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL1462692 | 0.99 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL41704 | 0.99 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL2732205 | 0.99 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL15300969 | 0.99 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL5987941 | 0.98 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12545 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116850183-B | Methods and pharmaceutical compositions for treating myopia | GRAND PHARMA (CHINA) Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122094664-A | An ophthalmically acceptable aqueous liquid composition comprising a muscarinic acetylcholine receptor antagonist | — | 2026-05-26 | — | — | CN | claimed |
| US-12629360-B2 | Ophthalmic composition | Sydnexis, Inc. (US) | 2026-05-19 | — | — | US | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4717276-A2 | OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER | University of Canberra (AU) | 2026-04-01 | — | — | EP | claimed |
| EP-4706766-A2 | TOPICAL OPHTHALMOLOGICAL COMPOSITIONS | ADS Therapeutics LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-12544400-B2 | Treatment of myopic progression | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2026-02-10 | — | — | US | claimed |
| US-12485177-B2 | Topical ophthalmological compositions | ADS THERAPEUTICS LLC (US) | 2025-12-02 | — | — | US | claimed |
| EP-3442516-B1 | OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER | UNIV CANBERRA (AU) | 2025-11-12 | — | — | EP | claimed |
| EP-4642463-A1 | PHARMACEUTICAL COMPOSITIONS OF GREEN PROPELLANT | Cipla Limited (IN) | 2025-11-05 | — | — | EP | claimed |
| US-4288958-A | Horizontal siding panel system with vertical stringers | ALCAN ALUMINUM CORPORATION (US) | 1981-09-15 | — | — | US | claimed |
| US-4286808-A | Snap-in tee connector | HANCOR, INC. (US) | 1981-09-01 | — | — | US | claimed |
| US-4256747-A | ANTIINFLAMMATORY AGENTS, PYRIDO/2,3B//1,4/BENZODIAZEPIN-6-ONES | BOEHRINGER INGELHEIM GMBH (DE) | 1981-03-17 | — | — | US | claimed |
| US-4246714-A | Multi-sided display device | ROTHCHILD PRINTING COMPANY, INC. (US) | 1981-01-27 | — | — | US | claimed |
| EP-0022589-A2 | A package for use in a beverage dispenser | Cadbury Schweppes Limited (GB) | 1981-01-21 | — | — | EP | claimed |
| US-4230150-A | Tilting disc check valve | SCARAMUCCI, JOHN P. | 1980-10-28 | — | — | US | claimed |
| EP-0002391-A1 | Crash-bottom carton and blank therefor | DRG (UK) LIMITED (GB) | 1979-06-13 | — | — | EP | claimed |
| US-4154833-A | INDOMETHACIN (1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID) WITH PIRENZEPINE (5,11-DIHYDRO-11-((4-METHYL-1-PIPERAZINYL)-ACETYL)-6H-PYRIDO(2,3 -B)(1,4)BENZODIAZEPIN-6-ONE) | BOEHRINGER INGELHEIM GMBH (DE) | 1979-05-15 | — | — | US | claimed |
| EP-0001626-A1 | Injection blow molding apparatus method | ETHYL CORPORATION (US) | 1979-05-02 | — | — | EP | claimed |
| US-4102233-A | Upright harpsichord action | KERN EVAN J | 1978-07-25 | — | — | US | claimed |