Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27467816 | 0.82 | NPC1 (0.47) | NPC1RAB9ACA2ADRB2ADRB1 | |
| SCHEMBL25159032 | 0.81 | NPC1 (0.53) | NPC1RAB9ACA2KDM4EMAPT | |
| SCHEMBL9087368 | 0.77 | EPHX2 (0.43) | NPC1RAB9ACA2ADRB2ADRB1 | |
| SCHEMBL9087370 | 0.77 | EPHX2 (0.43) | NPC1RAB9ACA2ADRB2ADRB1 | |
| SCHEMBL9237734 | 0.77 | RAB9A (0.61) | NPC1RAB9ACA2MAPTPOLB | |
| SCHEMBL9237730 | 0.77 | RAB9A (0.61) | NPC1RAB9ACA2MAPTPOLB | |
| SCHEMBL2486907 | 0.77 | PRSS1 (0.49) | KDM4ELMNAMEN1POLBKMT2A | |
| SCHEMBL9087240 | 0.75 | P2RY12 (0.42) | NPC1RAB9ACA2ADRB2ADRB1 | |
| SCHEMBL9556410 | 0.75 | P2RY12 (0.42) | NPC1RAB9ACA2ADRB2ADRB1 | |
| SCHEMBL9087244 | 0.75 | P2RY12 (0.42) | NPC1RAB9ACA2ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012419-B2 | Methods and compositions related to eosinophil regulation | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2015-04-21 | — | — | US | disclosed |
| US-20100016410-A1 | Methods and Compositions Related to Eosinophil Regulation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016410-A1 | Methods and Compositions Related to Eosinophil Regulation | EPX, CCL11, ELANE | NPC1 2078/4885RAB9A 1532/4885CA2 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.