SCHEMBL3487135

SCHEMBL3487135

N=C(N)NCCC[C@H](N)C(=O)OC(=O)[C@@H](N)CS

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.36
▸ NPY4R P50391 7/20 0.36
▸ NPY1R P25929 5/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ DPP7 Q9UHL4 1/20 0.34
▸ OTC P00480 1/20 0.34
▸ NPY2R P49146 4/20 0.33
▸ NPY5R Q15761 4/20 0.33
▸ DDAH1 O94760 1/20 0.33
▸ NOS3 P29474 1/20 0.33
▸ NOS1 P29475 1/20 0.33
▸ NOS2 P35228 1/20 0.33
▸ PTGS1 P23219 1/20 0.32
▸ SLC7A11 Q9UPY5 1/20 0.32
▸ FNTA P49354 2/20 0.31
▸ FNTB P49356 2/20 0.31
▸ PGGT1B P53609 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28712062 0.92 NPY4R (0.39) ALOX15NPY4RNPY1RMEN1CYP1A2
SCHEMBL288133 0.92 NPY4R (0.39) ALOX15NPY4RNPY1RMEN1CYP1A2
SCHEMBL9237239 0.92 NPY4R (0.39) ALOX15NPY4RNPY1RMEN1CYP1A2
Hydrochloric Acid SCHEMBL8040222 0.91 NPY4R (0.38) ALOX15NPY4RNPY1RMEN1CYP1A2
Hydrochloric Acid SCHEMBL8039440 0.91 NPY4R (0.38) ALOX15NPY4RNPY1RMEN1CYP1A2
SCHEMBL27722340 0.88 NPY4R (0.37) ALOX15NPY4RNPY1RMEN1CYP1A2
SCHEMBL16194087 0.87 NPY4R (0.38) ALOX15NPY4RNPY1RMEN1CYP1A2
SCHEMBL7061485 0.87 NPY4R (0.38) ALOX15NPY4RNPY1RMEN1CYP1A2
SCHEMBL769420 0.86 GNAI3 (0.40) ALOX15NPY4RNPY1RMEN1CYP1A2
SCHEMBL1840068 0.86 NPY4R (0.36) ALOX15NPY4RNPY1RMEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090325227-A1 C-TERMINUS MODIFICATION METHOD, C-TERMINUS IMMOBILIZATION METHOD AND ANALYSIS METHOD FOR PROTEIN OR PEPTIDE SHIMADZU CORPORATION (JP) 2009-12-31 — — US claimed
US-4996292-A Self-sealing artificial skin comprising copoly-alpha-amino acid FOX SIDNEY W (US) 1991-02-26 — — US claimed
US-20240132599-A1 MULTISPECIFIC ANTI-TCR DELTA VARIABLE 1 ANTIBODIES ADAPTATE BIOTHERAPEUTICS LIMITED (GB) 2024-04-25 — — US disclosed
CN-115491418-A Second-generation sequencing panel of target genes with congenital incomplete lens dislocation and sequencing method 复旦大学附属眼耳鼻喉科医院 2022-12-20 — — CN disclosed
US-20160215347-A1 LaFORA'S DISEASE GENE THE HOSPITAL FOR SICK CHILDREN (CA) 2016-07-28 — — US disclosed
US-9334539-B2 Lafora's disease gene THE HOSPITAL FOR SICK CHILDREN (CA) 2016-05-10 — — US disclosed
US-20150216948-A1 CYTOCHROME P450 SUICIDE GENE SYSTEM HANENBERG HELMUT (US) 2015-08-06 — — US disclosed
US-20140057971-A1 LaFORA'S DISEASE GENE THE HOSPITAL FOR SICK CHILDREN (CA) 2014-02-27 — — US disclosed
EP-2669378-A1 Cytochrome P450 suicide gene system Hanenberg, Helmut (US) 2013-12-04 — — EP disclosed
US-8486624-B2 Lafora's disease gene THE HOSPITAL FOR SICK CHILDREN (CA) 2013-07-16 — — US disclosed
US-20100009346-A1 Lafora's disease gene THE HOSPITAL FOR SICK CHILDREN 2010-01-14 — — US disclosed
EP-1499303-A2 MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM Miller, Fred H. (US) 2005-01-26 — — EP disclosed
US-6825328-B1 Lafora's disease gene THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-11-30 — — US disclosed
US-20040234538-A1 Derp1 and proderp1 allergen derivatives GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2004-11-25 — — US disclosed
WO-2003086267-A2 MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM MILLER FRED H (US) 2003-10-23 — — WO disclosed
US-20030181372-A1 Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2003-09-25 — — US disclosed
EP-0975798-A1 METHOD TO DIAGNOSE AND TREAT PATHOLOGICAL CONDITIONS RESULTING FROM DEFICIENT ION TRANSPORT SUCH AS PSEUDOHYPOALDOSTERONISM TYPE-1 YALE UNIVERSITY (US) 2000-02-02 — — EP disclosed
WO-1998040516-A1 METHOD TO DIAGNOSE AND TREAT PATHOLOGICAL CONDITIONS RESULTING FROM DEFICIENT ION TRANSPORT SUCH AS PSEUDOHYPOALDOSTERONISM TYPE-1 YALE UNIVERSITY (US) 1998-09-17 — — WO disclosed
EP-0504234-A1 ANTIBODIES PREVENTING INTERACTION BETWEEN A FRAGMENT Fc OF AN IMMUNOGLOBULIN AND ITS RECEIVER, AND THERAPEUTIC USE, PARTICULARILY IN TREATING AFFECTIONS LINKED TO THE HIV VIRUS JACQUILLAT, Annie (représentante légale de l'inventeur décédé) (FR) 1992-09-23 — — EP disclosed
WO-1991008301-A1 PROTEINS PREVENTING INTERACTION BETWEEN A FRAGMENT Fc OF AN IMMUNOGLOBULIN AND ITS RECEIVER, AND THERAPEUTIC USE, PARTICULARILY IN TREATING AFFECTIONS LINKED TO THE HIV VIRUS UNIVERSITE PIERRE ET MARIE CURIE (FR) 1991-06-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150216948-A1 CYTOCHROME P450 SUICIDE GENE SYSTEM CYP4B1, CYP4A11, CYP2E1 ALOX15 430/4885NPY4R 2960/4885NPY1R 3236/4885
US-20090325227-A1 C-TERMINUS MODIFICATION METHOD, C-TERMINUS IMMOBILIZATION METHOD AND ANALYSIS METHOD FOR PROTEIN OR PEPTIDE PTMS, ANPEP, DNPEP ALOX15 3939/4885NPY4R 1625/4885NPY1R 2196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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