Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14626264 | 0.89 | HSP90AB1 (0.51) | HSP90AB1GAAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL17385731 | 0.89 | HSP90AB1 (0.55) | HSP90AB1GAAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL14420070 | 0.89 | HSP90AB1 (0.55) | HSP90AB1GAAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL2977953 | 0.89 | HSP90AB1 (0.76) | HSP90AB1GAAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL1868343 | 0.87 | HSP90AB1 (0.53) | HSP90AB1GAAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL7802725 | 0.87 | HSP90AB1 (0.53) | HSP90AB1GAAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL18554389 | 0.87 | HSP90AB1 (0.53) | HSP90AB1GAAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL18554422 | 0.84 | HSP90AB1 (0.50) | HSP90AB1GAAKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL21891794 | 0.84 | HSP90AB1 (0.75) | HSP90AB1GAAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL14420104 | 0.83 | PTGS2 (0.54) | HSP90AB1CYP4F2CYP4A11GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112142733-A | Synthetic route of pan FGFR covalent inhibitor PRN1371 | 湖南师范大学 | 2020-12-29 | — | — | CN | claimed |
| EP-3334735-B1 | PROCESSES FOR PREPARING AN FGFR INHIBITOR | PRINCIPIA BIOPHARMA INC (US) | 2025-08-13 | — | — | EP | disclosed |
| US-12281110-B2 | Processes for preparing an FGFR inhibitor | PRINCIPIA BIOPHARMA, INC. (US) | 2025-04-22 | — | — | US | disclosed |
| US-12162882-B2 | Quinolone derivatives as fibroblast growth factor receptor inhibitors | PRINCIPIA BIOPHARMAC, INC. (US) | 2024-12-10 | — | — | US | disclosed |
| US-20240309000-A1 | Process for Preparing an FGFR Inhibitor | PRINCIPIA BIOPHARMA, INC. (US) | 2024-09-19 | — | — | US | disclosed |
| US-11999732-B2 | P2X3 receptor antagonists | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2024-06-04 | — | — | US | disclosed |
| US-20240092777-A1 | Quinolone Derivatives as Fibroblast Growth Factor Receptor Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2024-03-21 | — | — | US | disclosed |
| CN-112584898-B | P2X 3 Receptor antagonists | 瑞蔻达蒂化学和制药工业股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-11555036-B2 | FGFR4 inhibitor, preparation method therefor and pharmaceutical use thereof | ABBISKO THERAPEUTICS CO., LTD. (CN) | 2023-01-17 | — | — | US | disclosed |
| US-20220348573-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO., LTD. (CN) | 2022-11-03 | — | — | US | disclosed |
| EP-1581531-A1 | PYRIDINO[2,3-D]PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004056822-A1 | PYRIDINO `2, 3-D! PYRIMIDINE DERIVATIVES AS SELECTIVE KDR AND FGFR INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-08 | — | — | WO | disclosed |
| US-20040122029-A1 | Novel dihydropyridinone compounds | LIU JIN-JUN (US) | 2004-06-24 | — | — | US | disclosed |
| WO-2003076403-A1 | 1,2-DISUBSTITUDED-6-OXO-3-PHENYL-PIPERIDINE-3-CARBOXAMIDES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2003-09-18 | — | — | WO | disclosed |
| US-20030171588-A1 | 1,2-disubstituted-6-oxo-3-phenyl-piperidine-3-carboxamides and combinatorial libraries thereof | LION BIOSCIENCE AG (DE) | 2003-09-11 | — | — | US | disclosed |
| CN-1113872-C | Tricyclicbenzo [3] isoindole and benzo (h) isoquinoline | HOFFMANN LA ROCHE (CH) | 2003-07-09 | — | — | CN | disclosed |
| CN-1243510-A | Tricyclicbenzo [3] isoindole and benzo (h) isoquinoline | HOFFMANN LA ROCHE (CH) | 2000-02-02 | — | — | CN | disclosed |
| US-4072716-A | Bicycloalkane derivatives | SCHERING AKTIENGESELLSCHAFT (DT) | 1978-02-07 | — | — | US | disclosed |
| US-4051188-A | NOVEL BICYCLOALKANE DERIVATIVES AND THE PRODUCTION THEREOF | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-09-27 | — | — | US | disclosed |
| US-4008253-A | Bicycloalkanes | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240309000-A1 | Process for Preparing an FGFR Inhibitor | FGFR1, FGFR2, FGFR3 | HSP90AB1 1108/4885GAA 1578/4885KDM4E 647/4885 |
| US-20030171588-A1 | 1,2-disubstituted-6-oxo-3-phenyl-piperidine-3-carboxamides and combinatorial libraries thereof | BRD4, BICRA, HDAC6 | HSP90AB1 1894/4885GAA 1719/4885KDM4E 407/4885 |
| US-12281110-B2 | Processes for preparing an FGFR inhibitor | FGFR2, FGFR1, FGFR3 | HSP90AB1 1092/4885GAA 1652/4885KDM4E 741/4885 |
| US-12162882-B2 | Quinolone derivatives as fibroblast growth factor receptor inhibitors | FGFR1, FGFR3, FGFR2 | HSP90AB1 577/4885GAA 144/4885KDM4E 2775/4885 |
| US-20220348573-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | FGFR4, FGFR2, FGFR1 | HSP90AB1 332/4885GAA 2159/4885KDM4E 1448/4885 |
| US-11555036-B2 | FGFR4 inhibitor, preparation method therefor and pharmaceutical use thereof | FGFR4, FGFR2, FGFR1 | HSP90AB1 383/4885GAA 2105/4885KDM4E 1375/4885 |
| US-20240092777-A1 | Quinolone Derivatives as Fibroblast Growth Factor Receptor Inhibitors | FGFR1, FGFR3, FGFR2 | HSP90AB1 577/4885GAA 144/4885KDM4E 2775/4885 |
| US-20040122029-A1 | Novel dihydropyridinone compounds | FGFR1, FGFR3, FGFR4 | HSP90AB1 1276/4885GAA 3016/4885KDM4E 743/4885 |
| US-11999732-B2 | P2X3 receptor antagonists | P2RX3, P2RX5, P2RX2 | HSP90AB1 2843/4885GAA 2415/4885KDM4E 4316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.