Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.75 |
| ▸ | BCHE | P06276 | 9/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | GSR | P00390 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494230 | 1.00 | ALDH1A1 (0.75) | ALDH1A1BCHEMAPTGSRCA2 | |
| SCHEMBL3489939 | 1.00 | ALDH1A1 (0.75) | ALDH1A1BCHEMAPTGSRCA2 | |
| SCHEMBL31538809 | 0.94 | BCHE (0.71) | ALDH1A1BCHEMAPTGSRCA2 | |
| SCHEMBL7413928 | 0.88 | ALDH1A1 (0.72) | ALDH1A1BCHEMAPTGSRCA2 | |
| SCHEMBL3491547 | 0.88 | ALDH1A1 (0.72) | ALDH1A1BCHEMAPTGSRCA2 | |
| SCHEMBL3489944 | 0.88 | ALDH1A1 (0.72) | ALDH1A1BCHEMAPTGSRCA2 | |
| SCHEMBL3489942 | 0.88 | ALDH1A1 (0.72) | ALDH1A1BCHEMAPTGSRCA2 | |
| SCHEMBL7417455 | 0.88 | ALDH1A1 (0.72) | ALDH1A1BCHEMAPTGSRCA2 | |
| SCHEMBL3494232 | 0.88 | ALDH1A1 (0.72) | ALDH1A1BCHEMAPTGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL309369 | 0.87 | ALDH1A1 (1.00) | ALDH1A1BCHEMAPTGSRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326652-B1 | NITRO DERIVATIVES OF FURASEMIDE AND THEIR USE AS DIURETICS | MERCK SHARP & DOHME (US) | 2014-04-16 | — | — | EP | claimed |
| US-20100029678-A1 | DIURETICS | MERCK SHARP & DOHME CORP. | 2010-02-04 | — | — | US | claimed |
| EP-2326652-B1 | NITRO DERIVATIVES OF FURASEMIDE AND THEIR USE AS DIURETICS | MERCK SHARP & DOHME (US) | 2014-04-16 | — | — | EP | disclosed |
| US-20100029678-A1 | DIURETICS | MERCK SHARP & DOHME CORP. | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029678-A1 | DIURETICS | NR3C2, REN, NR3C1 | ALDH1A1 2059/4885BCHE 2877/4885MAPT 4222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.