Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | KDM5A | P29375 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | MLYCD | O95822 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492157 | 0.85 | KDM5A (0.55) | HDAC3HDAC1HDAC2HDAC6KDM5A | |
| SCHEMBL31141594 | 0.82 | HDAC3 (0.82) | HDAC3HDAC1HDAC2HDAC6MLYCD | |
| SCHEMBL3493497 | 0.81 | GPR52 (0.57) | HDAC3HDAC1HDAC2HDAC6AURKA | |
| SCHEMBL2715062 | 0.79 | MLYCD (0.58) | NR3C2MLYCDMEN1PLA2G1BCYP1A2 | |
| SCHEMBL3494002 | 0.78 | HDAC3 (0.54) | HDAC3HDAC1HDAC2HDAC6KDM5A | |
| SCHEMBL1767683 | 0.78 | MAPK14 (0.60) | HDAC1NR3C2AURKAMLYCDMEN1 | |
| SCHEMBL2714261 | 0.77 | MLYCD (0.56) | NR3C2MLYCDMEN1PLA2G1BCYP1A2 | |
| SCHEMBL2717072 | 0.76 | BRAF (0.61) | NR3C2AURKAMLYCDMEN1PLA2G1B | |
| SCHEMBL2717704 | 0.76 | SCN9A (0.57) | NR3C2MLYCDMEN1PLA2G1BCYP1A2 | |
| SCHEMBL5210610 | 0.76 | MLYCD (0.64) | HDAC3HDAC1HDAC2HDAC6MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492378-B2 | GSK-3β inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20100069381-A1 | GSK-3BETAINHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069381-A1 | GSK-3BETAINHIBITOR | GSK3B, GSK3A, GSKIP | HDAC3 96/4885HDAC1 102/4885HDAC2 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.