Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | VNN1 | O95497 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491530 | 0.84 | L3MBTL1 (0.52) | HDAC3HDAC1HDAC2HDAC6L3MBTL1 | |
| SCHEMBL3492011 | 0.78 | HDAC3 (0.57) | HDAC3HDAC1HDAC2HDAC6CYP1A2 | |
| SCHEMBL3492934 | 0.76 | HDAC3 (0.51) | HDAC3HDAC1HDAC2HDAC6CYP1A2 | |
| SCHEMBL16220824 | 0.75 | NOS2 (0.72) | L3MBTL1CYP1A2CYP3A4ALOX15CLK4 | |
| SCHEMBL11155559 | 0.75 | KDM4E (0.49) | L3MBTL1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5209577 | 0.74 | MMP13 (0.73) | L3MBTL1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL5471374 | 0.74 | KDM5B (0.75) | CYP1A2CYP3A4CYP2D6KDM5AKDM4C | |
| SCHEMBL3948160 | 0.73 | ALDH1A1 (0.77) | HDAC3HDAC1HDAC2HDAC6L3MBTL1 | |
| SCHEMBL18466143 | 0.72 | L3MBTL1 (0.53) | L3MBTL1CYP1A2CYP3A4ALOX15CLK4 | |
| SCHEMBL22084564 | 0.72 | VNN1 (0.60) | HDAC3HDAC1HDAC2HDAC6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492378-B2 | GSK-3β inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20100069381-A1 | GSK-3BETAINHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069381-A1 | GSK-3BETAINHIBITOR | GSK3B, GSK3A, GSKIP | HDAC3 96/4885HDAC1 102/4885HDAC2 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.