Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 16/20 | 0.35 |
| ▸ | GNA15 | P30679 | 1/20 | 0.34 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.34 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.34 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3493902 | 0.85 | DHODH (0.36) | NOTUM | |
| SCHEMBL3494703 | 0.85 | NR1H2 (0.34) | NOTUMNR1H2NR1H3 | |
| SCHEMBL3494598 | 0.84 | CA1 (0.39) | NOTUMNR1H2NR1H3FFAR1 | |
| SCHEMBL3494290 | 0.84 | NOTUM (0.34) | NOTUMNR1H2NR1H3 | |
| SCHEMBL3494807 | 0.83 | NOTUM (0.34) | NOTUMNR1H2NR1H3 | |
| SCHEMBL3495943 | 0.82 | NR1H2 (0.46) | NR1H2NR1H3SLC5A1 | |
| SCHEMBL3492462 | 0.81 | REN (0.45) | NOTUMFFAR1GNA15SLC10A1ABCC2 | |
| SCHEMBL3496195 | 0.81 | CNR2 (0.35) | NOTUMNR1H2NR1H3 | |
| SCHEMBL3495945 | 0.78 | NOTUM (0.34) | NOTUMFFAR1GNA15SLC10A1ABCC2 | |
| SCHEMBL3493775 | 0.77 | CPT2 (0.38) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | REN, AGTR1, AGTR2 | NOTUM 1289/4885NR1H2 339/4885NR1H3 293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.