Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.84 |
| ▸ | POLG | P54098 | 2/20 | 0.81 |
| ▸ | POLA1 | P09884 | 1/20 | 0.81 |
| ▸ | HPRT1 | P00492 | 11/20 | 0.66 |
| ▸ | PNP | P00491 | 6/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gs-438 SCHEMBL64567 | 0.96 | POLB (0.80) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL30760008 | 0.90 | POLB (1.00) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL8905164 | 0.89 | HPRT1 (0.72) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL9053832 | 0.88 | HPRT1 (0.74) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL8905172 | 0.88 | HPRT1 (0.71) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL2734697 | 0.87 | POLB (0.77) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL8896276 | 0.86 | HPRT1 (0.81) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL15545141 | 0.86 | HPRT1 (0.81) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL8717524 | 0.85 | POLB (0.81) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL24721833 | 0.85 | POLB (0.74) | POLBPOLGPOLA1HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143332-A1 | COMBINATION THERAPY FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| EP-2086644-A2 | COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008063558-A2 | COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |