Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13059953 | 0.84 | NOTUM (0.57) | NOTUMMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL5332602 | 0.83 | ACLY (0.53) | NOTUMMAPK1MEN1KMT2ATRIM24 | |
| SCHEMBL3492186 | 0.80 | NOTUM (0.49) | NOTUMMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL13347826 | 0.80 | NOTUM (0.49) | NOTUMMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL14058949 | 0.77 | ACLY (0.53) | NOTUMMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7140297 | 0.76 | NOTUM (0.54) | NOTUMALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL21469178 | 0.76 | NOTUM (0.54) | NOTUMKMT2AALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL32673770 | 0.76 | NOTUM (0.54) | NOTUMALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4808175 | 0.76 | NOTUM (0.67) | NOTUMMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL20939536 | 0.75 | NOTUM (0.57) | NOTUMALDH1A1SMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851606-B2 | Negatively charged minor groove binders | ELITECH HOLDING B.V. (NL) | 2010-12-14 | — | — | US | disclosed |
| US-7851606-B2 | Negatively charged minor groove binders | ELITECH HOLDING B.V. (NL) | 2010-12-14 | — | — | US | disclosed |
| US-20100137614-A1 | NEGATIVELY CHARGED MINOR GROOVE BINDERS | EPOCH BIOSCIENCES, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100137614-A1 | NEGATIVELY CHARGED MINOR GROOVE BINDERS | EPOCH BIOSCIENCES, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-7582739-B2 | Negatively charged minor groove binders | EPOCH BIOSCIENCES, INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582739-B2 | Negatively charged minor groove binders | EPOCH BIOSCIENCES, INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050187383-A1 | Negatively charged minor groove binders | LUKHTANOV, EUGENE | 2005-08-25 | — | — | US | disclosed |
| WO-2003078450-A2 | NEGATIVELY CHARGED MINOR GROOVE BINDERS | EPOCH BIOSCIENCES, INC. (US) | 2003-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187383-A1 | Negatively charged minor groove binders | PCNA, NCL, HNRNPH3 | NOTUM 2268/4885MAPK1 4861/4885MEN1 4719/4885 |
| US-20100137614-A1 | NEGATIVELY CHARGED MINOR GROOVE BINDERS | PCNA, NCL, HNRNPH3 | NOTUM 2268/4885MAPK1 4861/4885MEN1 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.