Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITPR3 | Q14573 | 8/20 | 0.63 |
| ▸ | ITPR1 | Q14643 | 4/20 | 0.63 |
| ▸ | ITPR2 | Q14571 | 3/20 | 0.63 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.55 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664274 | 0.92 | ITPR3 (0.74) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL5056860 | 0.89 | ITPR3 (0.68) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL4343591 | 0.88 | ITPR3 (0.74) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL4343592 | 0.88 | ITPR3 (0.74) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL19712146 | 0.88 | ITPR3 (0.65) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL5176539 | 0.88 | ITPR3 (0.65) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL237183 | 0.86 | ITPR3 (0.67) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL219762 | 0.86 | ITPR3 (0.67) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL220555 | 0.86 | ITPR3 (0.67) | ITPR3ITPR1ITPR2INPP5AINPPL1 | |
| SCHEMBL11233751 | 0.84 | ITPR3 (0.60) | ITPR3ITPR1ITPR2INPP5AINPPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100129806-A1 | REGULATION OF CELL SURVIVAL BY HSP90 AND IP6K2 | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2008073382-A9 | HSP90 AND IP6K2 BINDING | UNIV JOHNS HOPKINS (US) | 2009-06-18 | — | — | WO | disclosed |
| WO-2008073382-A2 | HSP90 AND IP6K2 BINDING | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-06-19 | — | — | WO | disclosed |