Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3499206 | 0.89 | MAPT (0.33) | NPC1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1653985 | 0.89 | ALDH1A1 (0.36) | NPC1KMT2AABCB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1653715 | 0.86 | ALDH1A1 (0.33) | KMT2AABCB1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1653422 | 0.86 | ALDH1A1 (0.35) | NPC1KMT2AABCB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1653124 | 0.85 | ALDH1A1 (0.35) | NPC1ABCB1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13675256 | 0.84 | ALDH1A1 (0.36) | NPC1ABCB1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3499070 | 0.84 | TAS2R14 (0.32) | MAPT | |
| SCHEMBL1654294 | 0.84 | ABCB1 (0.37) | NPC1KMT2AABCB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1655906 | 0.83 | ALDH1A1 (0.34) | ABCB1ALDH1A1SMN1; SMN2HPGDNR1H3 | |
| SCHEMBL1653389 | 0.83 | ALDH1A1 (0.34) | NPC1KMT2AALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410087-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-04-02 | — | — | US | disclosed |
| US-20100144702-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144702-A1 | INDOLE COMPOUND | GCKR, GPR119, SLC5A1 | NPC1 2480/4885KMT2A 507/4885ABCB1 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.