SCHEMBL350062

SCHEMBL350062

[NH]C(=O)c1ccc(Cl)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.62
CES1 P23141 3/20 0.62
TSHR P16473 2/20 0.59
ALOX15 P16050 1/20 0.59
CA1 P00915 2/20 0.56
CA2 P00918 2/20 0.56
GSK3B P49841 2/20 0.52
MAPK1 P28482 2/20 0.52
SRD5A2 P31213 1/20 0.52
LMNA P02545 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
ALDH1A1 P00352 2/20 0.50
KDM4E B2RXH2 1/20 0.50
MAPT P10636 1/20 0.50
POLB P06746 1/20 0.47
CYP3A4 P08684 1/20 0.46
ATM Q13315 1/20 0.46
PTGS2 P35354 1/20 0.45
ERCC5 P28715 1/20 0.45
FEN1 P39748 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6854413 0.87 HPGD (0.48) CES2CES1TSHRALOX15CA1
SCHEMBL273857 0.77 CES2 (1.00) CES2CES1TSHRALOX15CA1
SCHEMBL51827 0.77 SRD5A2 (0.80) CES2CES1TSHRALOX15CA1
SCHEMBL9065412 0.77 SRD5A2 (0.80) CES2CES1TSHRALOX15CA1
SCHEMBL2000442 0.77 CES2 (0.68) CES2CES1TSHRALOX15CA1
SCHEMBL10697158 0.77 SRD5A2 (0.80) CES2CES1TSHRALOX15CA1
SCHEMBL1681512 0.77 SRD5A2 (0.80) CES2CES1TSHRALOX15CA1
SCHEMBL12274592 0.76 SRD5A2 (0.70) CES2CES1TSHRALOX15CA1
SCHEMBL4088043 0.76 CES2 (0.58) CES2CES1TSHRALOX15CA1
Hydrochloric Acid SCHEMBL11704986 0.74 SRD5A2 (0.76) CES2CES1TSHRALOX15CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 652 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110291246-B Method for dyeing and foaming thermoplastic polyurethanes 亨茨曼国际有限公司 2022-07-05 CN claimed
US-10876252-B2 Process for dyeing and foaming thermoplastic polyurethane HUNTSMAN INTERNATIONAL LLC (US) 2020-12-29 US claimed
US-20200063338-A1 PROCESS FOR DYEING AND FOAMING THERMOPLASTIC POLYURETHANE HUNTSMAN INTERNATIONAL LLC 2020-02-27 US claimed
EP-3541988-A1 PROCESS FOR DYEING AND FOAMING THERMOPLASTIC POLYURETHANE Huntsman International LLC (US) 2019-09-25 EP claimed
US-20180153830-A1 SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2018-06-07 US claimed
WO-2018091446-A1 PROCESS FOR DYEING AND FOAMING THERMOPLASTIC POLYURETHANE HUNTSMAN INTERNATIONAL LLC (US) 2018-05-24 WO claimed
EP-2182950-B1 USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS HELPERBY THERAPEUTICS LTD (GB) 2017-07-19 EP claimed
US-20170027890-A1 SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2017-02-02 US claimed
US-9198426-B2 Use of 5 pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-01 US claimed
US-20150322094-A1 USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2015-11-12 US claimed
EP-0298917-A2 Process for dyeing a highly polymeric organic material with pigments on the basis of iminoisoindoline CIBA-GEIGY AG (CH) 1989-01-11 EP claimed
US-4751288-A COLORFASTNESS BASF AKTIENGESELLSCHAFT (DE) 1988-06-14 US claimed
US-4604460-A ANTIBIOTICS, BACTERICIDES SHIONOGI & CO., LTD. (JP) 1986-08-05 US claimed
US-4581453-A ANTICOAGULANT, FUNGICIDE, OR ANTILIPEMIC AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1986-04-08 US claimed
US-4443598-A ANTIBIOTICS AND INTERMEDIATES SHIONOGI & CO., LTD. (JP) 1984-04-17 US claimed
US-4225706-A Polychalcogen ester of cephem compound, process for preparing the same and method for removing the protective group of the same MEIJI SEIKA KAISHA LTD. (JP) 1980-09-30 US claimed
EP-0003663-A2 Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them AMERICAN CYANAMID COMPANY (US) 1979-08-22 EP claimed
US-4159265-A Phenylazopyrazolo dyestuffs including disulfimide substituent BAYER AKTIENGESELLSCHAFT (DE) 1979-06-26 US claimed
US-4014892-A ANTHELMINTICS AMERICAN CYANAMID COMPANY (US) 1977-03-29 US claimed
US-3987026-A POLYESTERS CIBA-GEIGY CORPORATION (US) 1976-10-19 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180153830-A1 SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS MCL1, MKI67, SCD CES2 2080/4885CES1 434/4885TSHR 4443/4885
US-20150322094-A1 USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS CAT, HSF1, HPD CES2 1061/4885CES1 1114/4885TSHR 4556/4885
US-20170027890-A1 SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS MCL1, MKI67, SCD CES2 2080/4885CES1 434/4885TSHR 4443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.