SCHEMBL3500908

SCHEMBL3500908

NS(=O)(=O)c1cc(Cl)c(Cl)cc1S(N)(=O)=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 15/20 0.56
CA2 P00918 15/20 0.56
CA9 Q16790 13/20 0.56
CA12 O43570 11/20 0.56
CA4 P22748 6/20 0.56
CA6 P23280 5/20 0.56
CA5A P35218 5/20 0.56
CA7 P43166 5/20 0.56
CA14 Q9ULX7 5/20 0.56
CA5B Q9Y2D0 5/20 0.56
CA3 P07451 3/20 0.56
CA13 Q8N1Q1 3/20 0.54
APEX1 P27695 2/20 0.54
LMNA P02545 1/20 0.54
CYP2C9 P11712 1/20 0.54
POLB P06746 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
CISD1 Q9NZ45 1/20 0.48
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6038485 0.89 CA1 (0.64) CA1CA2CA9CA12CA4
SCHEMBL5014186 0.88 CA1 (0.70) CA1CA2CA9CA12CA4
SCHEMBL9698646 0.85 CA1 (0.55) CA1CA2CA9CA12CA4
SCHEMBL9515970 0.85 CA1 (0.59) CA1CA2CA9CA12CA4
SCHEMBL1807804 0.85 CA1 (0.79) CA1CA2CA9CA12CA4
SCHEMBL5245480 0.85 CA1 (0.55) CA1CA2CA9CA12CA4
SCHEMBL5012991 0.83 CA1 (0.49) CA1CA2CA9CA12CA4
SCHEMBL2777644 0.83 CA1 (0.47) CA1CA2CA9CA12CA4
SCHEMBL1807802 0.83 CA1 (0.47) CA1CA2CA9CA12CA4
SCHEMBL3264937 0.78 CA1 (0.42) CA1CA2CA9CA12CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0036351-B1 OPHTHALMIC COMPOSITIONS OF CARBONIC ANHYDRASE INHIBITORS FOR TOPICAL APPLICATION IN THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE MERCK & CO. INC. (US) 1985-01-02 EP claimed
EP-0014642-B1 OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF CARBONIC ANHYDRASE INHIBITORS AND S-(-)-1-(TERT-BUTYLAMINO)-3-(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)-OXY-2-PROPANOL FOR TOPICAL APPLICATION IN THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE MERCK & CO. INC. (US) 1984-03-21 EP claimed
EP-0036351-A2 Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure MERCK & CO. INC. (US) 1981-09-23 EP claimed
EP-0033042-A1 Ophthalmic inserts for lowering intraocular pressure comprising carbonic anhydrase inhibitors MERCK & CO. INC. (US) 1981-08-05 EP claimed
EP-0014642-A2 Ophthalmic compositions comprising combinations of carbonic anhydrase inhibitors and S-(-)-1-(tert-butylamino)-3-(4-morpholino-1,2,5-thiadiazol-3-yl)-oxy-2-propanol for topical application in the treatment of elevated intraocular pressure MERCK & CO. INC. (US) 1980-08-20 EP claimed
US-20160369237-A1 METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY ADVANCED CELL TECH INC (US) 2016-12-22 US disclosed
US-20100184033-A1 METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY Lineage Cell Therapeutics, Inc. 2010-07-22 US disclosed
US-20080226601-A1 Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods UNIVERSITY OF ROCHESTER (US) 2008-09-18 US disclosed
EP-1903873-A2 HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS THE UNIVERSITY OF ROCHESTER (US) 2008-04-02 EP disclosed
US-20080070303-A1 Using myocardial and/or muscle progenitor cells as modeling tool in tissue engineering; regenerative medicine and organ replacement ADVANCED CELL TECHNOLOGY 2008-03-20 US disclosed
WO-2007062198-A1 METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY ADVANCED CELL TECHNOLOGY, INC. (US) 2007-05-31 WO disclosed
WO-2006135602-A2 HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS UNIVERSITY OF ROCHESTER (US) 2006-12-21 WO disclosed
US-5157044-A Treating glaucoma UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1992-10-20 US disclosed
US-5095026-A PRODRUGS OF CARBONIC ANHYDRASE INHIBITORS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1992-03-10 US disclosed
EP-0036351-B1 OPHTHALMIC COMPOSITIONS OF CARBONIC ANHYDRASE INHIBITORS FOR TOPICAL APPLICATION IN THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE MERCK & CO. INC. (US) 1985-01-02 EP disclosed
US-4438123-A Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure MERCK & CO., INC. (US) 1984-03-20 US disclosed
EP-0036351-A2 Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure MERCK & CO. INC. (US) 1981-09-23 EP disclosed