SCHEMBL9515970

SCHEMBL9515970

Nc1cc(S(N)(=O)=O)c(S(N)(=O)=O)cc1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 13/20 0.59
CA2 P00918 13/20 0.59
CA9 Q16790 11/20 0.59
CA12 O43570 8/20 0.59
CA4 P22748 7/20 0.59
CA6 P23280 6/20 0.59
CA5A P35218 6/20 0.59
CA7 P43166 6/20 0.59
CA14 Q9ULX7 6/20 0.59
CA5B Q9Y2D0 6/20 0.59
CA3 P07451 3/20 0.59
APEX1 P27695 2/20 0.52
POLB P06746 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
GAA P10253 1/20 0.50
CA13 Q8N1Q1 3/20 0.47
CYP2C9 P11712 2/20 0.47
LMNA P02545 1/20 0.47
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1806519 0.88 CA1 (0.76) CA1CA2CA9CA12CA4
SCHEMBL3500908 0.85 CA1 (0.56) CA1CA2CA9CA12CA4
SCHEMBL1807804 0.81 CA1 (0.79) CA1CA2CA9CA12CA4
SCHEMBL11132234 0.81 CA1 (0.79) CA1CA2CA9CA12CA4
SCHEMBL5014186 0.79 CA1 (0.70) CA1CA2CA9CA12CA4
Hydrochloric Acid SCHEMBL11139867 0.79 CA1 (0.76) CA1CA2CA9CA12CA4
SCHEMBL9327134 0.79 ALDH1A1 (0.50) CA1CA2CA9CA12CA4
SCHEMBL11497077 0.78 PKM (0.71) CA1CA2CA9CA12CA4
SCHEMBL17774552 0.76 CA2 (0.65) CA1CA2CA9CA12CA4
SCHEMBL9698646 0.76 CA1 (0.55) CA1CA2CA9CA12CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0539527-A1 ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1993-05-05 EP disclosed
US-5157044-A Treating glaucoma UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1992-10-20 US disclosed
US-5095026-A PRODRUGS OF CARBONIC ANHYDRASE INHIBITORS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1992-03-10 US disclosed
WO-1992000287-A2 ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1992-01-09 WO disclosed