Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146329 | 0.85 | KDM4E (0.42) | ALDH1A1HSD17B10TSHRCFTRKDM4E | |
| L-Kynurenine SCHEMBL9636977 | 0.79 | KDM4E (0.49) | ALDH1A1HSD17B10CFTRKDM4EHIF1A | |
| SCHEMBL4458686 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HSD17B10TSHRCFTRKDM4E | |
| SCHEMBL288333 | 0.71 | MAPT (0.43) | ALDH1A1HSD17B10TSHRCFTRKDM4E | |
| SCHEMBL5388881 | 0.71 | MAPT (0.43) | ALDH1A1HSD17B10TSHRCFTRKDM4E | |
| SCHEMBL7673421 | 0.71 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TSHRCFTRKDM4E | |
| SCHEMBL4351788 | 0.70 | ALDH1A1 (0.50) | ALDH1A1HSD17B10TSHRCFTRKDM4E | |
| SCHEMBL22368114 | 0.70 | MAPT (0.42) | ALDH1A1HSD17B10TSHRCFTRKDM4E | |
| SCHEMBL22053899 | 0.70 | MAPT (0.42) | ALDH1A1HSD17B10TSHRCFTRKDM4E | |
| SCHEMBL17623476 | 0.70 | MAPT (0.42) | ALDH1A1HSD17B10TSHRCFTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173418-A1 | Polypeptides with Reduced Susceptibility to Oxidation and Methods of Making | AMGEN INC. | 2010-07-08 | — | — | US | disclosed |
| US-20080038258-A1 | Polypeptides with Reduced Susceptibility to Oxidation and Methods of Making | AMGEN INC. (US) | 2008-02-14 | — | — | US | disclosed |