Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dimetacrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.47 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.47 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 0.47 |
| ▸ | OPRM1 known ✓ | P35372 | 5/20 | 0.47 |
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.47 |
| ▸ | CHRM4 known ✓ | P08173 | 4/20 | 0.47 |
| ▸ | ADRA2B known ✓ | P18089 | 4/20 | 0.47 |
| ▸ | ADRA2C known ✓ | P18825 | 4/20 | 0.47 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.47 |
| ▸ | OPRK1 known ✓ | P41145 | 4/20 | 0.47 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.47 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.47 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.47 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.47 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.42 |
| ▸ | OPRD1 known ✓ | P41143 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimetacrine SCHEMBL3501514 | 1.00 | CYP2D6 (0.75) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| Dimetacrine SCHEMBL29578094 | 0.87 | CYP2D6 (1.00) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| Dimetacrine SCHEMBL50120 | 0.87 | CYP2D6 (1.00) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| SCHEMBL11640552 | 0.79 | CYP2D6 (0.78) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| Dimetacrine SCHEMBL28221926 | 0.73 | HRH1 (0.71) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| SCHEMBL13231573 | 0.71 | KMT2A (0.68) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| SCHEMBL17739604 | 0.70 | KMT2A (0.68) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| SCHEMBL11640659 | 0.70 | KMT2A (0.63) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| Imipramine SCHEMBL20644144 | 0.69 | SLC6A4 (0.83) | CYP2D6CYP1A2KMT2ALMNAMAPT | |
| SCHEMBL21027093 | 0.69 | TP53 (0.51) | CYP2D6CYP1A2KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8231899-B2 | An orally-administered drug having low solubility in acid environment, e.g. stomach, being a powder contacted with water to form particules where >50% pass through sieve 180 mu m; in 0.07 N hydrochloric acid >50% released within 20 min.; high strength tablets; bioavailability; drug delivery | NYCOMED DANMARK APS (DK) | 2012-07-31 | — | — | US | disclosed |
| US-20100184033-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | Lineage Cell Therapeutics, Inc. | 2010-07-22 | — | — | US | disclosed |
| US-20080226601-A1 | Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods | UNIVERSITY OF ROCHESTER (US) | 2008-09-18 | — | — | US | disclosed |
| EP-1903873-A2 | HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS | THE UNIVERSITY OF ROCHESTER (US) | 2008-04-02 | — | — | EP | disclosed |
| EP-1850854-A1 | ROOM TEMPERATURE STABLE AQUEOUS LIQUID PHARMACEUTICAL COMPOSITION | Biomarin Pharmaceutical Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006135602-A2 | HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS | UNIVERSITY OF ROCHESTER (US) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006093493-A1 | ROOM TEMPERATURE STABLE AQUEOUS LIQUID PHARMACEUTICAL COMPOSITION | BIOMARIN PHARMACEUTICAL INC. (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060013834-A1 | Room temperature stable aqueous liquid pharmaceutical composition | MEDICIS PEDIATRICS, INC. (US) | 2006-01-19 | — | — | US | disclosed |
| US-20050147668-A1 | Quick release pharmaceutical compositions of drug substances | NYCOMED DANMARK A/S | 2005-07-07 | — | — | US | disclosed |
| US-6713089-B1 | UNDER ACIDIC CONDITIONS; NONSTEROID ANTIINFLAMMATORY NSAID; CRUSHING STRENGTH | NYCOMED DANMARK A/S (DK) | 2004-03-30 | — | — | US | disclosed |
| EP-1017370-B1 | MODIFIED RELEASE MULTIPLE-UNITS COMPOSITIONS OF NON-STEROID ANTI-INFLAMMATORY DRUG SUBSTANCES (NSAIDs) | NYCOMED DANMARK APS (DK) | 2003-10-29 | — | — | EP | disclosed |
| US-6599529-B1 | Fast acting; sustained release | NYCOMED DANMARK A/S (DK) | 2003-07-29 | — | — | US | disclosed |
| EP-1109534-B1 | QUICK RELEASE PHARMACEUTICAL COMPOSITIONS OF DRUG SUBSTANCES | NYCOMED DANMARK AS (DK) | 2003-02-12 | — | — | EP | disclosed |
| EP-1109534-A1 | QUICK RELEASE PHARMACEUTICAL COMPOSITIONS OF DRUG SUBSTANCES | NYCOMED DANMARK A/S (DK) | 2001-06-27 | — | — | EP | disclosed |
| EP-1017370-A1 | MODIFIED RELEASE MULTIPLE-UNITS COMPOSITIONS OF NON-STEROID ANTI-INFLAMMATORY DRUG SUBSTANCES (NSAIDs) | NYCOMED DANMARK A/S (DK) | 2000-07-12 | — | — | EP | disclosed |
| WO-2000015195-A1 | QUICK RELEASE PHARMACEUTICAL COMPOSITIONS OF DRUG SUBSTANCES | NYCOMED DANMARK A/S (DK) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999012524-A1 | MODIFIED RELEASE MULTIPLE-UNITS COMPOSITIONS OF NON-STEROID ANTI-INFLAMMATORY DRUG SUBSTANCES (NSAIDs) | NYCOMED DANMARK A/S (DK) | 1999-03-18 | — | — | WO | disclosed |