Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTP4A3 | O75365 | 1/20 | 0.59 |
| ▸ | SNRNP200 | O75643 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | POLB | P06746 | 7/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 3/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 2/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.55 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503222 | 0.89 | PTP4A3 (0.74) | PTP4A3SNRNP200MEN1KMT2APOLB | |
| SCHEMBL3503224 | 0.89 | PTP4A3 (0.74) | PTP4A3SNRNP200MEN1KMT2APOLB | |
| SCHEMBL22523765 | 0.73 | SNRNP200 (0.88) | PTP4A3SNRNP200MEN1KMT2APOLB | |
| SCHEMBL19652472 | 0.72 | GSK3A (0.79) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL31358664 | 0.71 | PIM1 (0.72) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL10091431 | 0.70 | PIM1 (0.62) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL20847906 | 0.70 | GSK3A (0.74) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL23777557 | 0.70 | XPA (0.62) | MEN1KMT2APOLBTDP1MAPT | |
| SCHEMBL31434402 | 0.70 | PIM1 (0.73) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL12177382 | 0.68 | POLB (0.66) | MEN1KMT2APOLBTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160067257-A1 | SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY | THE WISTAR INSTITUTE (US) | 2016-03-10 | — | — | US | disclosed |
| US-9234230-B2 | Screening method and compounds for modulating telomerase activity | THE WISTAR INSTITUTE (US) | 2016-01-12 | — | — | US | disclosed |
| US-8377992-B2 | TRBD-binding effectors and methods for using the same to modulate telomerase activity | THE WISTAR INSTITUTE (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120309759-A1 | Screening Method and Compounds for Modulating Telomerase Activity | THE WISTAR INSTITUTE (US) | 2012-12-06 | — | — | US | disclosed |
| US-20100160260-A1 | TRBD-Binding Effectors and Methods for Using the Same to Modulate Telomerase Activity | THE WISTAR INSTITUTE | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309759-A1 | Screening Method and Compounds for Modulating Telomerase Activity | TERT, TERB1, TERF2 | PTP4A3 932/4885SNRNP200 2863/4885MEN1 3807/4885 |
| US-20160067257-A1 | SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY | TERT, TERB1, TERF2 | PTP4A3 932/4885SNRNP200 2863/4885MEN1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.