Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5459124 | 0.88 | ROCK2 (0.67) | ROCK2ROCK1RAB9ANPC1TP53 | |
| SCHEMBL3504526 | 0.87 | NAMPT (0.65) | ROCK2ROCK1RAB9ANPC1TP53 | |
| SCHEMBL3502187 | 0.85 | ROCK2 (0.67) | ROCK2ROCK1RAB9ANPC1TP53 | |
| SCHEMBL3270932 | 0.84 | RAB9A (0.77) | RAB9ANPC1TP53ALOX15SMN1; SMN2 | |
| SCHEMBL2790882 | 0.84 | ROCK2 (0.58) | ROCK2ROCK1RAB9ANPC1TP53 | |
| SCHEMBL3501386 | 0.84 | ROCK2 (0.64) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3271513 | 0.82 | RAB9A (0.77) | RAB9ANPC1TP53ALOX15SMN1; SMN2 | |
| SCHEMBL2793073 | 0.81 | ROCK2 (0.62) | ROCK2ROCK1RAB9ANPC1TP53 | |
| SCHEMBL2796251 | 0.81 | NAMPT (0.66) | ROCK2ROCK1RAB9ANPC1TP53 | |
| SCHEMBL5456383 | 0.81 | KMT2A (0.72) | RAB9ANPC1TP53ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190788-A1 | Amide derivatives as kinase inhitors | DEVGEN N.V. (BE) | 2010-07-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190788-A1 | Amide derivatives as kinase inhitors | MAP3K1, MAPK1, MAP3K21 | ROCK2 24/4885ROCK1 10/4885RAB9A 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.