Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SDHB | P21912 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3505214 | 0.89 | KDM4E (0.39) | EGFRERBB2GAALMNAMAPT | |
| SCHEMBL3507108 | 0.83 | MEN1 (0.48) | GAALMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL3506911 | 0.75 | ALDH1A1 (0.59) | LMNAMAPTKDM4ETDP1ALDH1A1 | |
| SCHEMBL2747848 | 0.73 | EGFR (0.53) | EGFRERBB2MAPTMRGPRX4ERBB3 | |
| SCHEMBL29638122 | 0.73 | EGFR (0.53) | EGFRERBB2MAPTMRGPRX4ERBB3 | |
| SCHEMBL22043798 | 0.72 | NPSR1 (0.37) | GAAMAPTKDM4ETDP1ALDH1A1 | |
| SCHEMBL7187883 | 0.71 | MAOB (0.55) | GAAMAPTALDH1A1PDE7AMRGPRX4 | |
| SCHEMBL2747591 | 0.71 | EGFR (0.50) | EGFRERBB2GAAMAPTALDH1A1 | |
| SCHEMBL9316857 | 0.70 | ALDH1A1 (0.43) | GAALMNAMAPTKDM4ETDP1 | |
| SCHEMBL3508248 | 0.70 | L3MBTL1 (0.37) | EGFRERBB2MAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216788-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216788-A1 | FUSED HETEROCYCLIC COMPOUND | GRK6, FGFR1, PTK6 | EGFR 54/4885ERBB2 31/4885GAA 3460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.