Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 7/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16961478 | 0.98 | PNMT (0.42) | PNMTMAPK8CSNK1A1LIMK1MAP2K1 | |
| SCHEMBL31707285 | 0.87 | PNMT (0.46) | PNMTMAPK8CSNK1A1LIMK1MAP2K1 | |
| SCHEMBL3715448 | 0.85 | PTPRC (0.42) | PNMTMAPK8CSNK1A1LIMK1PRKAA1 | |
| SCHEMBL25363152 | 0.83 | APEX1 (0.38) | PNMTADORA1PARP1PARP2APEX1 | |
| Hydrochloric Acid SCHEMBL27077080 | 0.78 | ADORA1 (0.44) | LIMK1DYRK1ACLK4DYRK1BADORA1 | |
| Trifluoroacetic Acid SCHEMBL30055363 | 0.77 | PTPRC (0.37) | MAPK8CSNK1A1LIMK1PRKAA1DYRK1A | |
| SCHEMBL6318336 | 0.76 | ADORA1 (0.59) | ADORA1HPGDMEN1ALDH1A1MAPT | |
| SCHEMBL1292074 | 0.76 | MAPK1 (0.45) | HPGDALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL6408001 | 0.75 | HPGD (0.54) | HPGDMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL3121683 | 0.75 | HPGD (0.58) | HPGDMEN1ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119161358-B | 4,5,6, 7-Tetrahydrothiophene [2,3-c ] pyridine-3-carboxamide compound and preparation method and application thereof | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| EP-4313994-B1 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARM SPA (IT) | 2025-03-05 | — | — | EP | claimed |
| CN-119161358-A | 4,5,6, 7-Tetrahydrothiophene [2,3-c ] pyridine-3-carboxamide compound and preparation method and application thereof | 沈阳药科大学 | 2024-12-20 | — | — | CN | claimed |
| EP-4313293-A1 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | claimed |
| CN-117098764-A | Tetrahydrothienopyridine derivatives as DDR inhibitors | 奇斯药制品公司 | 2023-11-21 | — | — | CN | claimed |
| WO-2022200580-A1 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | claimed |
| CN-119161358-B | 4,5,6, 7-Tetrahydrothiophene [2,3-c ] pyridine-3-carboxamide compound and preparation method and application thereof | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | disclosed |
| CN-119161358-B | 4,5,6, 7-Tetrahydrothiophene [2,3-c ] pyridine-3-carboxamide compound and preparation method and application thereof | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | disclosed |
| EP-4313293-B1 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARM SPA (IT) | 2025-05-07 | — | — | EP | disclosed |
| EP-4506349-A2 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2025-02-12 | — | — | EP | disclosed |
| CN-119161358-A | 4,5,6, 7-Tetrahydrothiophene [2,3-c ] pyridine-3-carboxamide compound and preparation method and application thereof | 沈阳药科大学 | 2024-12-20 | — | — | CN | disclosed |
| CN-119161358-A | 4,5,6, 7-Tetrahydrothiophene [2,3-c ] pyridine-3-carboxamide compound and preparation method and application thereof | 沈阳药科大学 | 2024-12-20 | — | — | CN | disclosed |
| US-20240391936-A1 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-11-28 | — | — | US | disclosed |
| EP-2997367-A1 | METHOD TO IDENTIFY COMPOUNDS ABLE TO BIND TO THE ROSSMANN FOLD OF C-TERMINAL-BINDING PROTEINS, IDENTIFIED COMPOUNDS AND MEDICAL USES THEREOF | Consiglio Nazionale Delle Ricerche (IT) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014184370-A1 | METHOD TO IDENTIFY COMPOUNDS ABLE TO BIND TO THE ROSSMANN FOLD OF C-TERMINAL-BINDING PROTEINS, IDENTIFIED COMPOUNDS AND MEDICAL USES THEREOF | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2014-11-20 | — | — | WO | disclosed |
| US-8497283-B2 | Autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2013-07-30 | — | — | US | disclosed |
| US-20130023556-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-01-24 | — | — | US | disclosed |
| US-8329907-B2 | Autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2012-12-11 | — | — | US | disclosed |
| EP-2414346-A1 | AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240391936-A1 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | DDR1, DDR2, DDRGK1 | PNMT 4126/4885MAPK8 998/4885CSNK1A1 258/4885 |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | PNMT 2640/4885MAPK8 3052/4885CSNK1A1 2417/4885 |
| US-20130023556-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | PNMT 2640/4885MAPK8 3052/4885CSNK1A1 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.