Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 2/20 | 1.00 |
| ▸ | GRIA1 | P42261 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gyki-53655 SCHEMBL8192023 | 1.00 | GRIA2 (1.00) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| Gyki-53655 SCHEMBL30259941 | 1.00 | GRIA2 (1.00) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| Gyki-53655 SCHEMBL25271920 | 0.99 | GRIA2 (0.98) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| Gyki-53655 SCHEMBL30389810 | 0.99 | GRIA2 (0.98) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| SCHEMBL5881321 | 0.89 | GRIA2 (0.81) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| SCHEMBL30259935 | 0.89 | GRIA2 (0.81) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| Talampanel SCHEMBL118011 | 0.89 | GRIA2 (0.80) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| SCHEMBL118013 | 0.89 | GRIA2 (0.80) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| Talampanel SCHEMBL118012 | 0.89 | GRIA2 (0.80) | GRIA2GRIA1MEN1KMT2ACYP1A2 | |
| Talampanel SCHEMBL30272868 | 0.89 | GRIA2 (0.80) | GRIA2GRIA1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024102177-A1 | COMBINATION THERAPIES FOR THE TREATMENT OF BRAIN CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-05-16 | — | — | WO | claimed |
| EP-2255798-B1 | FTY720 for use in the treatment of optic neuritis | NOVARTIS AG (CH) | 2014-12-24 | — | — | EP | claimed |
| WO-2011076946-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALZHEIMER | Universidad Del País Vasco (ES) | 2011-06-30 | — | — | WO | claimed |
| US-7192931-B2 | Treatment of demyelinating diseases | NEUREN PHARMACEUTICALS LTD. (NZ) | 2007-03-20 | — | — | US | claimed |
| US-7101879-B2 | Treatments for neurotoxicity in Alzheimer's Disease | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2006-09-05 | — | — | US | claimed |
| US-20050182047-A1 | Treatment of demyelinating disorders | EISAI CO., LTD. (JP) | 2005-08-18 | — | — | US | claimed |
| US-20040204347-A1 | Treatment of demyelinating disorders | EISAI CO., LTD. (JP) | 2004-10-14 | — | — | US | claimed |
| US-6797692-B1 | Use of glutamate antagonists for the treatment of cancer | IKONOMIDOU HRISSANTHI (DE) | 2004-09-28 | — | — | US | claimed |
| WO-2004069195-A2 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISORDERS OF THE AIRWAYS | IVAX CORPORATION (US) | 2004-08-19 | — | — | WO | claimed |
| US-20040152694-A1 | Methods and compositions for treating inflammatory disorders of the airways | IVAX DRUG RESEARCH INSTITUTE, LTD. | 2004-08-05 | — | — | US | claimed |
| EP-1015013-A1 | TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY beta-AMYLOID PEPTIDES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-07-05 | — | — | EP | claimed |
| WO-2000024395-A1 | NEW USE OF GLUTAMATE ANTAGONISTS FOR THE TREATMENT OF CANCER | IKONOMIDOU HRISSANTHI (DE) | 2000-05-04 | — | — | WO | claimed |
| WO-2000001376-A2 | PHARMACEUTICAL COMPOSITIONS AND THEIR USES FOR TREATMENT OF DEMYELINATING DISORDERS | EISAI CO., LTD (JP) | 2000-01-13 | — | — | WO | claimed |
| WO-1998030229-A1 | TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY β-AMYLOID PEPTIDES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1998-07-16 | — | — | WO | claimed |
| US-5639751-A | N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders | CYOGYSZERKUTATO INTEZET KFT (HU) | 1997-06-17 | — | — | US | claimed |
| US-5604223-A | TREATING EPILEPSY, NERVOUS SYSTEM DISORDER | GYOGYSZERKUTATO INTEZET KFT. (HU) | 1997-02-18 | — | — | US | claimed |
| US-5536832-A | CENTRAL NERVOUS SYSTEM DISORDERS | GYOGYSZERKUTATO INTEZET KFT (HU) | 1996-07-16 | — | — | US | claimed |
| US-5521174-A | ANTISPASMODIC AGENTS | GYOGYSZERKUTATO INTEZET KV. (HU) | 1996-05-28 | — | — | US | claimed |
| US-5519019-A | NERVOUS SYSTEM DISORDERS AND MUSCLE RELAXANTS | GYOGYSZERKUTATO INTEZET (HU) | 1996-05-21 | — | — | US | claimed |
| US-5459137-A | Muscle relaxants, anticonvulsants, neuroprotective agents | GYOGYSZERKU-TATO INTEZET KFT (HU) | 1995-10-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204347-A1 | Treatment of demyelinating disorders | GRIK4, GRIK5, PMP22 | GRIA2 21/4885GRIA1 20/4885MEN1 3154/4885 |
| US-20040152694-A1 | Methods and compositions for treating inflammatory disorders of the airways | LTB4R2, LTB4R, LTC4S | GRIA2 2341/4885GRIA1 2085/4885MEN1 4621/4885 |
| US-20050182047-A1 | Treatment of demyelinating disorders | GRIK4, PMP22, GRIK5 | GRIA2 21/4885GRIA1 19/4885MEN1 3073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.