Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564791 | 0.81 | MAPT (0.44) | PTPN1PTPN6PTPN11TRPA1MAPT | |
| Hydrochloric Acid SCHEMBL9261456 | 0.79 | MAPT (0.43) | PTPN1PTPN6PTPN11TRPA1MAPT | |
| SCHEMBL1380931 | 0.79 | RAB9A (0.41) | PTPN1PTPN6PTPN11TRPA1MAPT | |
| SCHEMBL30466241 | 0.78 | TRPA1 (0.43) | PTPN1PTPN6PTPN11TRPA1MAPT | |
| SCHEMBL11259261 | 0.78 | — | — | |
| SCHEMBL7912 | 0.78 | — | — | |
| SCHEMBL4280891 | 0.74 | TSHR (0.38) | MAPTALDH1A1HPGD | |
| SCHEMBL6966817 | 0.72 | — | — | |
| SCHEMBL8865985 | 0.72 | TRPA1 (0.39) | PTPN1PTPN6PTPN11TRPA1MAPT | |
| SCHEMBL8866037 | 0.72 | TRPA1 (0.48) | PTPN1PTPN6PTPN11TRPA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285539-A | Preparation method of nalfurorphine | 山东新时代药业有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-115521317-A | Method for preparing nafrafine intermediate | 山东新时代药业有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-114621238-A | Method for preparing nafrafine | 鲁南制药集团股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| US-8946419-B2 | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives | MALLINCKRODT LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140031543-A1 | (+)-6-Hydroxy-Morphinan or (+)-6-Amino-Morphinan Derivatives | MALLINCKRODT LLC (US) | 2014-01-30 | — | — | US | disclosed |
| US-8563724-B2 | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives | MALLINCKRODT LLC (US) | 2013-10-22 | — | — | US | disclosed |
| EP-2398807-A1 | (+)-6-HYDROXY-MORPHINAN OR (+)-6-AMINO-MORPHINAN DERIVATIVES | Mallinckrodt LLC (US) | 2011-12-28 | — | — | EP | disclosed |
| US-20100216995-A1 | (+)-6-Hydroxy-Morphinan or (+)-6-Amino-Morphinan Derivatives | MALLINCKRODT INC. (US) | 2010-08-26 | — | — | US | disclosed |
| WO-2010096791-A1 | (+)-6-HYDROXY-MORPHINAN OR (+)-6-AMINO-MORPHINAN DERIVATIVES | MALLINCKRODT INC. (US) | 2010-08-26 | — | — | WO | disclosed |
| EP-0787721-B1 | 4a-ARYLDECAHYDROISOQUINOLINE COMPOUNDS AND MEDICINAL USES THEREOF | TORAY INDUSTRIES (JP) | 1999-04-28 | — | — | EP | disclosed |
| US-5824670-A | ANTIINFLAMMATORY AGENTS; TREATING DERMATOSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-10-20 | — | — | US | disclosed |
| US-5776945-A | CARDIOVASCULAR, CEREBRAL CYTOPROTECTIVE | TORAY INDUSTRIES, INC. (JP) | 1998-07-07 | — | — | US | disclosed |
| EP-0787721-A1 | 4a-ARYLDECAHYDROISOQUINOLINE COMPOUNDS AND MEDICINAL USES THEREOF | TORAY INDUSTRIES, INC. (JP) | 1997-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216995-A1 | (+)-6-Hydroxy-Morphinan or (+)-6-Amino-Morphinan Derivatives | GRM6, HTR6, GRIN3B | PTPN1 3509/4885PTPN6 1716/4885PTPN11 3450/4885 |
| US-20140031543-A1 | (+)-6-Hydroxy-Morphinan or (+)-6-Amino-Morphinan Derivatives | GRM6, HTR6, GRIN3B | PTPN1 3509/4885PTPN6 1716/4885PTPN11 3450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.