Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.72 |
| ▸ | CA4 | P22748 | 1/20 | 0.72 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.54 |
| ▸ | GRM8 | O00222 | 2/20 | 0.50 |
| ▸ | GRM6 | O15303 | 2/20 | 0.50 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.50 |
| ▸ | OTC | P00480 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pala SCHEMBL59449 | 0.85 | CA2 (1.00) | CA2CA4FOLH1OTC | |
| Sparfosic Acid SCHEMBL3514530 | 0.85 | CA2 (1.00) | CA2CA4FOLH1OTC | |
| Sparfosic Acid SCHEMBL31237824 | 0.83 | CA2 (0.96) | CA2CA4FOLH1OTC | |
| Pala SCHEMBL859680 | 0.83 | CA2 (0.96) | CA2CA4FOLH1OTC | |
| Pala SCHEMBL11121904 | 0.83 | CA2 (0.96) | CA2CA4FOLH1OTC | |
| Pala SCHEMBL31389020 | 0.83 | CA2 (0.96) | CA2CA4FOLH1OTC | |
| SCHEMBL12990268 | 0.83 | CA2 (0.71) | CA2CA4FOLH1 | |
| SCHEMBL3513056 | 0.83 | CA2 (0.71) | CA2CA4FOLH1 | |
| SCHEMBL10423054 | 0.82 | NOD1 (0.57) | CA2CA4FOLH1GRM8GRM6 | |
| SCHEMBL9225913 | 0.82 | NOD1 (0.57) | CA2CA4FOLH1GRM8GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100303715-A1 | Prostate-specific membrane antigen and uses thereof | ISRAELI RON S | 2010-12-02 | — | — | US | disclosed |
| US-7399461-B2 | Prostate-specific membrane antigen and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2008-07-15 | — | — | US | disclosed |
| EP-1754788-A2 | Prostate-specific membrane antigen and uses thereof | Sloan-Kettering Institute For Cancer Research (US) | 2007-02-21 | — | — | EP | disclosed |
| US-7037647-B1 | Prostate-specific membrane antigen and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2006-05-02 | — | — | US | disclosed |
| US-20040253246-A1 | Prostate-specific membrane antigen and uses thereof | ISRAELI RON S (US) | 2004-12-16 | — | — | US | disclosed |
| EP-0812356-A4 | PROSTATE-SPECIFIC MEMBRANE ANTIGEN AND USES THEREOF | SLOAN KETTERING INST CANCER (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0812356-A1 | PROSTATE-SPECIFIC MEMBRANE ANTIGEN AND USES THEREOF | Sloan-Kettering Institute For Cancer Research (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026272-A1 | PROSTATE-SPECIFIC MEMBRANE ANTIGEN AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1996-08-29 | — | — | WO | disclosed |