Pala

Pala

SCHEMBL59449

O=C(O)C[C@H](NC(=O)CP(=O)(O)O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 4/20 1.00
CA4 P22748 1/20 1.00
ENO1 P06733 1/20 0.43
MEN1 O00255 1/20 0.43
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43
TSHR P16473 1/20 0.43
BLM P54132 1/20 0.43
KMT2A Q03164 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
FOLH1 Q04609 1/20 0.42
RECQL P46063 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CASP3 P42574 1/20 0.42
OTC P00480 1/20 0.40
CA1 P00915 2/20 0.40
MME P08473 2/20 0.39
ENPEP Q07075 2/20 0.38
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sparfosic Acid SCHEMBL3514530 1.00 CA2 (1.00) CA2CA4ENO1MEN1LMNA
Sparfosic Acid SCHEMBL31237824 0.98 CA2 (0.96) CA2CA4ENO1MEN1LMNA
Pala SCHEMBL11121904 0.98 CA2 (0.96) CA2CA4ENO1MEN1LMNA
Pala SCHEMBL31389020 0.98 CA2 (0.96) CA2CA4ENO1MEN1LMNA
Pala SCHEMBL859680 0.98 CA2 (0.96) CA2CA4ENO1MEN1LMNA
SCHEMBL7747522 0.85 CA2 (0.74) CA2CA4ENO1MEN1KMT2A
Pala SCHEMBL3514468 0.85 CA2 (0.72) CA2CA4FOLH1OTC
SCHEMBL3513056 0.84 CA2 (0.71) CA2CA4HPGDFOLH1GGH
SCHEMBL12990268 0.84 CA2 (0.71) CA2CA4HPGDFOLH1GGH
Sparfosic Acid SCHEMBL28558641 0.84 CA2 (0.72) CA2CA4ENO1MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5397 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
EP-4687871-A1 TOPICAL PALA THERAPY FOR CANCER The Cleveland Clinic Foundation (US) 2026-02-11 EP claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
US-20250268993-A1 ALKALINE PHOSPHATE-BASED ONCOLOGY TREATMENTS THERIVA BIOLOGICS, INC. 2025-08-28 US claimed
US-12364682-B2 Use of tegaserod in preparation of anti-tumor drug QINGDAO HAIJI BIOMEDICINE CO., LTD. (CN) 2025-07-22 US claimed
US-12318434-B2 Alkaline phosphate-based oncology treatments THERIVA BIOLOGICS, INC. (US) 2025-06-03 US claimed
US-20240343697-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2024-10-17 US claimed
WO-2024206402-A1 TOPICAL PALA THERAPY FOR CANCER THE CLEVELAND CLINIC FOUNDATION (US) 2024-10-03 WO claimed
EP-2796112-B2 Degradable implantable medical devices ELIXIR MEDICAL CORP (US) 2023-08-09 EP claimed
US-20220333137-A1 METHODS AND PRODUCTS FOR PRODUCING ENGINEERED MAMMALIAN CELL LINES WITH AMPLIFIED TRANSGENES PRECISION BIOSCIENCES, INC. (US) 2022-10-20 US claimed
EP-0160079-A4 METHOD AND MATERIALS FOR SENSITIZING NEOPLASTIC TISSUE TO RADIATION. GREER SHELDON B 1986-05-14 EP claimed
EP-0160079-A1 METHOD AND MATERIALS FOR SENSITIZING NEOPLASTIC TISSUE TO RADIATION. GREER SHELDON B 1985-11-06 EP claimed
WO-1985001871-A1 METHOD AND MATERIALS FOR SENSITIZING NEOPLASTIC TISSUE TO RADIATION GREER SHELDON B 1985-05-09 WO claimed
US-4442203-A OR ABNORMAL GENETIC LABILITY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1984-04-10 US claimed
US-4348522-A ANTITUMOR STARKS ASSOCIATES, INC. (US) 1982-09-07 US claimed
US-4267126-A ANTITUMOR AGENTS STARKS ASSOCIATES, INC. (US) 1981-05-12 US claimed
US-4215070-A DISODIUM SALT AS ANTITUMOR AGENT STARKS ASSOCIATES, INC. (US) 1980-07-29 US claimed
US-4179464-A Preparation of N-(phosphonoacetyl)-L-aspartic acid SCHULTZ ROBERT J 1979-12-18 US claimed
US-4178306-A Preparation of N-(phosphonoacetyl)-L-aspartic acid PARSONS JACK L 1979-12-11 US claimed
US-4154759-A Preparation of N-(phosphonoacetyl)-L-aspartic acid DUBICKI HENRYK 1979-05-15 US claimed