Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.55 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.55 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.55 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11845550 | 0.87 | SMN1; SMN2 (0.73) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL30028243 | 0.86 | MTNR1A (0.86) | MTNR1AMTNR1BALDH1A1BCHEAPP | |
| SCHEMBL17821714 | 0.85 | MAPT (0.74) | MAPTSMN1; SMN2ALDH1A1APPPKM | |
| SCHEMBL17821711 | 0.85 | MAPT (0.74) | MAPTSMN1; SMN2ALDH1A1APPPKM | |
| SCHEMBL25773443 | 0.85 | MTNR1A (0.69) | MTNR1AMTNR1BMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11716101 | 0.84 | MTNR1B (0.68) | MTNR1AMTNR1BMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18736058 | 0.84 | MTNR1A (0.72) | MTNR1AMTNR1BMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27781943 | 0.83 | MTNR1A (0.67) | MTNR1AMTNR1BSMN1; SMN2ALDH1A1BCHE | |
| SCHEMBL6376395 | 0.83 | MTNR1A (0.71) | MTNR1AMTNR1BMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12707505 | 0.82 | SLC2A1 (0.58) | MTNR1AMTNR1BMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100217003-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES | UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION (KR) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217003-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES | NFKBIA, HMOX1, PTGS1 | MTNR1A 434/4885MTNR1B 104/4885MAPT 1303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.